Novel cocrystallization

ABSTRACT

The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit under 35 U.S.C. §119(e) of U.S.Provisional Application Nos. 60/441,557 and 60/441,561, filed Jan. 21,2003. These applications are incorporated by reference herein.

FIELD OF THE INVENTION

The present disclosure describes cocrystals comprising active agents,especially active pharmaceutical ingredients (APIs), and methodsrelating to cocrystals. In particular, novel cocrystals are provided ofa salt of an active pharmaceutical ingredient (such as a salt havingchloride as the counterion) and a guest that forms a relatively stronginteraction with the counterion. Methods are provided for searching forpossible solid state phases of a sample and include solidifying thesample as a cocrystal. Methods are also provided for screening a samplefor solid state phases and include solidifying the sample as acocrystal.

BACKGROUND OF THE INVENTION

Cocrystals are crystals that contain two or more non-identicalmolecules. Examples of cocrystals may be found in the CambridgeStructural Database. Examples of cocrystals may also be found at Etter,Margaret C., and Daniel A. Adsmond (1990) “The use of cocrystallizationas a method of studying hydrogen bond preferences of 2-aminopyridine” J.Chem. Soc., Chem. Commun. 1990 589-591, Etter, Margaret C., John C.MacDonald, and Joel Bernstein (1990a) “Graph-set analysis ofhydrogen-bond patterns in organic crystals” Acta Crystallogr., Sect. B,Struct. Sci. B46 256-262, Etter, Margaret C., Zofia Urbańczyk-Lipkowska,Mohammad Zia-Ebrahimi, and Thomas W. Panunto (1990b) “Hydrogen bonddirected cocrystallization and molecular recognition properties ofdiarylureas” J. Am. Chem. Soc. 112 8415-8426, which are incorporatedherein by reference in their entireties. The following articles are alsoincorporated herein by reference in their entireties: Carl HenrikGörbotz and Hans-Petter Hersleth, 2000, “On the inclusion of solventmolecules in the crystal structures of organic compounds” Acta Cryst.(2000), B56, 625-534; and V. S. Senthil Kumar, Ashwini Nangia, Amy K.Katz and H. L. Carrell, 2002, “Molecular Complexes of Some Mono- andDicarboxylic Acids with trans-1,4,-Dithiane-1,4-dioxide” AmericanChemical Society, Crystal Growth & Design, Vol. 2, No. 4, 2002.

The identification of an optimal composition, formulation, and/or solidstate phase is important in the pharmaceutical field, as well as inother fields including nutraceuticals, agricultural chemicals, dyes,explosives, polymer additives, lubricant additives, photographicchemicals, and structural and electronic materials. The new methodsdescribed herein may be useful in any of these fields as well as otherswhere solid materials are used.

SUMMARY OF THE INVENTION

As one aspect, novel cocrystals are provided. The novel cocrystalscomprise one or more active agents, particularly of the salts of suchactive agents.

As another aspect, novel cocrystallization methods are provided whichhave increased probability of successful cocrystallization. A suitablemethod of cocrystallization may include identifying a crystal comprisinga salt of an active agent, wherein the salt comprises the active agentand a negative counterion. One may identify coordination of the negativecounterion (for example, its hydrogen bond interactions within thatcrystal). One may then select a guest to coordinate more strongly withthe negative counterion than the coordination within the crystal. Basedupon the evaluation of the nonbonded interactions involving onecomponent of an active agent and/or guest, one selects another moleculeor molecules or a salt that will coordinate well, or interact stronglywith a hydrogen bond acceptor site that has been identified as beinginvolved in a weak hydrogen bond. If the acceptor site has the abilityto interact with stronger hydrogen bond donors, and thus form a moreenergetically favorable interaction, yet it is presently involved in aweak interaction, then the opportunity exists to replace the weak donorwith a stronger one. For example, if a strong hydrogen bond acceptor isinteracting with a weak hydrogen bond donor in a crystal, a cocrystalcould be created by adding a strong hydrogen bond donor molecule to thesystem which would replace the weak donor and bond to the strongacceptor site in the resulting cocrystal. After the selection of asuitable guest, a solution, melt, or physical mixture comprising theactive agent, the counterion, and the guest may be prepared. Thesolution or melt is subjected to a crystallization process, such asevaporation, cooling, or any of the many well-known processes forforming a crystal from a solution or melt. The physical mixture can beground to form the cocrystal. A cocrystal is formed comprising the saltof the active agent and the guest.

As another aspect, the present disclosure provides a cocrystallizationmethod that produces a novel type of chloride salt cocrystal structure.The method can be useful for generating beneficial solid chloride saltsof APIs in cases where the chloride salt was previously disfavored.

As yet another aspect, novel forms of salts of active pharmaceuticalingredients are provided. For example, the present disclosure providesnovel cocrystals of fluoxetine HCl and benzoic acid; fluoxetine HCl andsuccinic acid; and fluoxetine HCl and fumaric acid. Novel forms or solidstate phases of active pharmaceutical ingredients may be prepared forwhich there are no known polymorphs, solvates or hydrates, or where suchpolymorphs, solvates or hydrates were disfavored.

As a further aspect, a method of modifying one or more physicalproperties of a drug formulation or drug composition which comprises anAPI, the method comprising forming a series of cocrystals of the APIwith a plurality of guests. The method may further comprise measuring aphysical property of the cocrystal and/or adjusting the drug formulationor drug composition.

As yet another aspect, an improved method for screening or selecting theoptimal solid state phase for active agents, particularly activepharmaceutical ingredients, and salts thereof, is provided. Thescreening method comprises crystallizing or attempting to crystallizethe free base of the active agent, a chloride salt of the active agent,and optionally other salts of the active agent, and cocrystallizing orattempting to cocrystallize the free base of the active agent, achloride salt of the active agent, and optionally other salts of theactive agent. The method may further comprise evaluating one or moreproperties of the solid forms, such as one or more physical properties.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1( a) and (b) illustrate a crystal structure of an activepharmaceutical ingredient and a cocrystal structure containing the sameAPI with a guest molecule.

FIGS. 2( a) and (b) are drawings of two-dimensional andthree-dimensional models of a cocrystal of fluoxetine HCl and benzoicacid (1:1).

FIGS. 3( a) and (b) are drawings of two-dimensional andthree-dimensional models of a cocrystal of fluoxetine HCl and succinicacid (2:1).

FIGS. 4( a) and (b) show a two-dimensional drawing of nabumetone and2,3-naphthalenediol and a three-dimensional model of a cocrystal ofnabumetone and 2,3-naphthalenediol (1:1).

FIG. 5 shows examples of general classes of guests.

DETAILED DESCRIPTION OF THE INVENTION

The present disclosure provides a way of investigating cocrystals and away of creating new solid state phases in which one or more activeagents are cocrystallized with a guest. By cocrystallizing an activeagent with a guest such as a pharmaceutically acceptable compound, onecan create new solid state phases which may have improved propertiesover existing solid state phases of that active agent. For example, newdrug formulations comprising cocrystals of active pharmaceuticalingredients may have superior properties over existing drugformulations. The active agent and guest will vary depending on theindustry. For example, in the pharmaceutical field, the active agent orguest may be an API, and the other component of the cocrystal must be apharmaceutically acceptable compound. The present techniques are alsoapplicable to active agents from other fields including nutraceuticals,agricultural chemicals, pigments, dyes, explosives, polymer additives,lubricant additives, photographic chemicals, and structural andelectronic materials.

Broadly speaking, one aspect relates to the use of undercoordinatedcounterions to facilitate cocrystallization. While the inventor does notwish to be bound to theory, the inventor believes excellent cocrystalsmay be formed using hydrochloride salts and similar salts which arestrong hydrogen bond acceptors yet contain relatively undercoordinatedions. “Undercoordinated” in this case refers to ions, for example achloride ion, that are able to form a number of strong hydrogen bonds.An undercoordinated counterion may have hydrogen bonds within a crystalof that salt, but it could form additional hydrogen bonds in a cocrystaland/or form relatively stronger hydrogen bonds in a cocrystal with aguest. An ion is “undercoordinated” when the system is limited in thenumber of hydrogen bond donors that are available and bonded to the ion.In these cases, the extra hydrogen bond acceptor sites are typicallyfilled by weakly interacting donors such as C—H groups. Chloride ionsare strong hydrogen bond acceptors in a crystal structure. In a crystalstructure such as fluoxetine hydrochloride, the chloride ion coordinatesto the two strong hydrogen bond donors available in the system, and thechloride ion also has three weaker CH—Cl interactions resulting in apseudo-octahedral coordination environment. There is an opportunity forbonding with these coordination sites, by displacing the weak CH donorsthat the chloride has recruited to fill its coordination sphere withsomewhat stronger hydrogen bond donors from a guest such as benzoicacid, succinic acid, fumaric acid, or another carboxylic acid.

It is useful in forming cocrystals to recognize that relatively weakinteractions may be replaced by stronger interactions, even though thosestronger interactions may be relatively weak themselves, compared toother interactions. For example, an undercoordinated chloride may haveone strong hydrogen bond donor and several weak hydrogen bond donors ortwo strong hydrogen bond donors and several weak hydrogen bond donors.In a cocrystal, weaker interactions may be replaced by strongerinteractions, although those stronger interactions may still be weakerthan the strong interactions (charge-assisted hydrogen bonds) present influoxetine HCl crystals. The strongest interactions involving chlorideions in crystal structures of organic salts are the charge assistedhydrogen bonds that invariably form between the protonated nitrogen baseand the chloride ion. The strongest interactions between neutralmolecular groups and the chloride ion involve acids and the chlorideion. Carboxylic acids, for instance, have strong interactions withchloride ions. It can be seen that a combination of carboxylic acids andhydrochloride salts of nitrogen containing bases are especially wellsuited to cocrystal formation (as demonstrated by the examplesincluded). Furthermore, it can be anticipated that differentcombinations of these elements could lead to other cocrystals. Forexample, the active molecule of interest may contain either the neutralcarboxylic acid moiety or the protonated nitrogen. The potential existsto cocrystallize an API having a neutral carboxylic acid moiety with aguest that is a hydrochloride salt of a nitrogen-containing organicbase.

It is further contemplated that the nature of the protonated nitrogenbase will affect the potential for cocrystallization. Numerous stronghydrogen bond donor groups will compete with the carboxylic acid guestfor the open acceptor sites on the chloride ion. In order to favorcocrystal formation, the nitrogen base is preferably a tertiary aminebecause this presents a situation where only one strong charged hydrogenbond donor exists and thus will only occupy one site on the chlorideacceptor. Additionally, systems that have only this one tertiary amineand no other strong donors present an especially favorable system forpotential cocrystallization. Protonated secondary amines with two N—Hdonor groups are also favored, although protonated primary amines mayalso be used. Special consideration must be taken for systems withadditional strong hydrogen bond donor and acceptor sites in order todetermine the potential for cocrystallization and the optimal guestmolecule type for cocrystallization. The potential for cocrystallizationinvolving a carboxylic acid and a hydrochloride salt may be reduced asthe number of available strong donors in the system is increased.Additional guidance as to evaluating undercoordination may be found inthe inventor's prior work (which is incorporated by reference herein inits entirety), particularly in its discussion of nonbonded motifs: ScottL. Childs, “Nonbonded Interactions In Molecular Crystal Structures”,Emory Univ., USA, available from UMI, Order No. DA3009424 (288 pp.),Dissertation Abstract-Int. Ref. B2001, 62(3), 1394. In somecircumstances, the undercoordination can be determined by measuringdistances, comparing profiles in the Cambridge Structural Database,measuring the pKa of the donors and acceptors, or evaluating the ratioof strong hydrogen bond donors to available acceptors. Other crystalengineering theories may also be used.

The formation of cocrystals is very unpredictable. It is difficult toforesee structural changes as a function of changes in molecularsubstitution patterns or in molecular geometry. However, the presentdisclosure provides greater predictability and better probability ofsuccess in designing and forming cocrystals.

The present techniques may be employed to generate a wide variety ofcocrystals of active agents and guests. For example, the presenttechniques may be used to generate cocrystals of a salt of an activeagent, such as a salt of an active pharmaceutical ingredient, with aneutral guest. Alternatively, a cocrystal of a neutral or zwitterionicactive agent (or a salt of an active agent) may be generated with aguest salt, which includes a positive ion and a negative ion of its own.Where the active agent is provided in a salt, it may be positively ornegatively charged and have a negative or positive counterion. As anexample, for fluoxetine HCl, the active agent fluoxetine is positivelycharged by virtue of accepting a proton from HCl to form a protonatedamine, and chloride is present as a negative counterion. Furthermore,some of the present methods may be employed with a neutral orzwitterionic active agent to form a cocrystal with a neutral guest orionic guest.

The present techniques provide an opportunity to create a stable solidstate phase of a hydrochloride salt of an API that was previously foundto have properties that were unsuitable for development. Opportunitiesfor continued development in such a situation have often relied on thefortuitous formation of a stable hydrate or solvate, but the presenttechniques present the ability to systematically examine alternativeformulations of the hydrochloride salt by cocrystallizing thehydrochloride salt of the API with appropriate guest molecules.

Cocrystallization may be an attractive technique for salts of APIs thathave been rejected due to problems relating to physical properties.Since cocrystals may have different physical properties than theindividual components, APIs with unfavorable physical properties can becocrystallized with suitable guest molecules and the physical propertiesof the resulting crystalline solids can be evaluated.

The cocrystals of fluoxetine HCl provide examples of the modification ofa physical property (solubility) of an API salt. Cocrystals offluoxetine HCl:benzoic acid are less soluble and have a lowerdissolution rate than crystals of fluoxetine HCl, while cocrystals offluoxetine HCl:succinic acid are more soluble and have a fasterdissolution rate than crystals of fluoxetine HCl.

Other physical properties of APIs or their salts that may be modified byforming a cocrystal include: melting point, density, hygroscopicity,crystal morphology, loading volume, compressibility, and shelf life.Furthermore, other properties such as bioavailability, toxicity, taste,physical stability, chemical stability, production costs, andmanufacturing method may be modified by the use of the presentcocrystallization techniques.

An active agent can be screened for possible cocrystals wherepolymorphic forms, hydrates or solvates are especially problematic. Aneutral compound that can only be isolated as amorphous material couldbe cocrystallized. Forming a cocrystal may up-grade the performance of adrug formulation of an active pharmaceutical ingredient by changingphysical properties. Some APIs are problematic during wet granulationand compression stages. A bioequivalent cocrystal could rectify thisproblem.

A cocrystal can be used to isolate or purify a compound duringmanufacturing. If it is desirable to identify all of the solid statephases of an active pharmaceutical ingredient, then cocrystallizationmay be particularly desirable.

The present techniques provide new methods of developing and screeningactive pharmaceutical ingredients. Non-toxic cocrystalline forms ofneutral active pharmaceutical ingredients may be prepared, screened,tested, and commercialized. Screening based on cocrystal formation isequivalent in many respects to a salt-screen for neutral APIs.Furthermore, new types of HCl salt structures may be prepared. Theproperties of hydrochloride salts can be tuned and perfected. New,unique, stable, and marketable phase of hydrochloride salts may beprepared. One can choose whether to make the formulation more soluble orless soluble.

As another aspect, the present techniques may also be used to remove orreduce the water of hydration, and/or to prepare a cocrystalsubstantially free of water of hydration. A hydrate may be viewed as acocrystal having water as the guest. Water and guest acids perform asimilar role in the stabilization of the crystal structure. In fact,about 28% of the hydrochloride salts of API in the Cambridge StructureDatabase are hydrates, compared to about 8% of all other organicstructures. This indicates an affinity for hydration. The presenttechniques both capitalize and rectify this affinity, in that anaffinity for cocrystallization (as evidence by hydration) is likelyindicated, and this affinity for cocrystallization may be employed forthe formation of cocrystals with a suitable guest, such as an acid, forexample a carboxylic acid. Indeed, in many cocrystals, an acid may havestronger interactions than water molecules and may displace the water ofhydration during the formation of the cocrystal. Accordingly, thepresent techniques provide a method of preparing a cocrystal from ahydrate. A hydrate of a salt is provided, and the hydrate compriseswater of hydration. A guest is selected to coordinate with thecounterion. Preferably, the guest coordinates more strongly with thecounterion than the solvent does. A solution, melt or physical mixtureis prepared which comprises the hydrate and the guest. The solution ormelt is subjected to a crystallization process, or the physical mixtureis subjected to grinding, and a cocrystal comprising the salt of theactive agent and the guest is formed, and the salt comprises the activeagent and a counterion. Similarly, the present techniques provide amethod of preparing a cocrystal from a solvate. A solvate of a salt isprovided, and the solvate comprises solvent molecules coordinated withthe salt. A guest is selected to coordinate with the counterion.Preferably, the guest coordinates more strongly with the counterion thanthe solvent does. A solution, melt or physical mixture is preparedcomprising the solvate and the guest. The solution or melt is subjectedto a crystallization process, or the physical mixture is subjected togrinding, and a cocrystal comprising the salt of the active agent andthe guest is formed. The salt comprises the active agent and acounterion.

FIGS. 2( a) and (b) are drawings of two-dimensional andthree-dimensional models of a cocrystal of fluoxetine HCl and benzoicacid (1:1). FIG. 2( a) shows a two-dimensional model in which thechloride ion interacts with the hydrogens of the amine group offluoxetine and of the hydroxyl group of benzoic acid. Through theseinteractions, which may be characterized as hydrogen bonding, fluoxetinehydrochloride and benzoic acid form a supramolecular structure that maybe the basis of a cocrystal. FIG. 2( b) shows a three-dimensional modelof the supramolecular organization of fluoxetine hydrochloride andbenzoic acid.

FIGS. 3( a) and (b) are drawings of two-dimensional andthree-dimensional models of a cocrystal of fluoxetine HCl and succinicacid (2:1). FIG. 3( a) shows a two-dimensional model in which thechloride ion interacts with the hydrogens of the ammonium group offluoxetine and of the hydroxyl group of succinic acid. Through theseinteractions, which may be characterized as hydrogen bonding, twomolecules of fluoxetine hydrochloride and one molecule of succinic acidform a supramolecular structure that may be the basis of a cocrystal.FIG. 3( b) shows a three-dimensional model of the supramolecularorganization of the molecules of fluoxetine hydrochloride and succinicacid.

FIGS. 4( a) and (b) show a two-dimensional drawing of nabumetone and2,3-naphthalenediol and a three-dimensional model of a cocrystal ofnabumetone and 2,3-naphthalenediol (1:1).

Active Agent

The active agent is the molecule whose activity is desirable or theobject of interest. It is contemplated that one or more active agentsmay be employed in a cocrystal, according to any of the presenttechniques. For example, where the active agent is an activepharmaceutical ingredient, the pharmaceutical activity of the activeagent is desirable. Other active agents may be nutraceuticals,agricultural chemicals, pigments, dyes, explosives, polymer additives,lubricant additives, photographic chemicals, or structural andelectronic materials.

The active agent may be provided as a salt. It is contemplated that oneor more salts may be employed in a cocrystal, according to any of thepresent techniques. The salt may be prepared from the active agent orobtained from a commercial source. Hydrochloride salts of activepharmaceutical ingredients, especially of amine APIs, are especiallypreferred in the pharmaceutical industry.

In general, it is contemplated that the present techniques will haveparticularly good results as applied to amine HCl salts as well as otherammonium salts as described in more detail herein. In ammonium acidsalts, the active agent has at least one amine moiety which isrelatively basic (at least one relatively basic nitrogen), and a salt isformed with an acid that reacts with the amine moiety. Cocrystals may bethen formed between the ammonium salts and guests which act ashydrogen-bond donors to the salts. Cocrystals may be formed of chloridesalts of APIs, for example buspirone hydrochloride, fluoxetinehydrochloride, and metformin hydrochloride.

The present cocrystals may comprise salts other than chloride salts—thehydrochloride API salts that are listed above are only a sampling of therelevant compounds because the starting material need not be a knownhydrochloride. Indeed, many relevant APIs are salts that are not HClsalts because the HCl salt was not believed to be an appropriatematerial and a different salt was commercialized instead. The presenttechniques may enable one to employ an HCl salt of an API that ismarketed as another type of salt. Alternatively, it may be desirable toemploy a salt other than an HCl salt, by replacing the HCl or by forminga salt comprising an active agent that acts as a base with an acid otherthan HCl. The following acids provide anionic counterions that would beused to replace chlorine. These are relatively strong acids, and includebut are not limited to mineral acids, and the carboxylic acid guest isexpected to form one or more hydrogen bonds with a hydrogen bondacceptor on the anionic counterion. The list is the conjugate acid thatwould react with a basic active agent to form a salt:

-   sulfuric acid-   phosphoric acid-   hydrobromic acid-   nitric acid-   pyrophosphoric acid-   methanesulfonic acid-   thiocyanic acid-   naphthalene-2-sulfonic acid-   1,5-naphthalenedisulfonic acid-   cyclamic acid-   p-toluenesulfonic acid-   maleic acid-   L-aspartic acid-   2-hydroxy-ethanesulfonic acid-   glycerophosphoric acid-   ethanesulfonic acid-   hydroiodic acid

The present techniques also extend beyond salts as starting materialsand also include many weak bases that may have been marketed as neutralforms because the known salts did not have appropriate properties. Thesesalts could be revisited and attempts could be made to cocrystallize theHCl salt. For example, a drug formulation marketed as a tartrate salt ofan API could be reformulated by cocrystallizing the HCl salt of theactive molecule with an appropriate guest molecule. Thus,cocrystallization could make a useful HCl cocrystal out of the API thatis currently marketed as a tartrate, sulfate, or other salt formulation.For this reason the present disclosure includes APIs that are not HClsalts as starting materials.

Furthermore, the present techniques relate to salts other than chloridesalts. It is contemplated that hydrobromide salts and sodium salts ofAPIs may especially benefit from the present techniques, since they formrelatively strong nonbonded interactions. For example, the hydrobromidesalts citalopram hydrobromide and galantamine hydrobromide arecontemplated for cocrystallization with benzoic acid, succinic acid, andother guests compatible with hydrochloride salts.

The present techniques may be employed to form cocrystals of sodiumsalts of APIs such as, for example, naproxen sodium, tolmetin sodium,and warfarin sodium. When a sodium salt (or other salt of an API havinga positive counterion) is employed, different guests are expected to besuitable for cocrystallization than when a hydrochloride salt (or otheranionic salt) of an API is employed.

Anions and Cations

As one aspect, the active agent is provided as a salt. A salt of theactive agent is formed. Alternatively or additionally, the guest isprovided as a salt or a salt of the guest is formed. The salt maycomprise the active agent and a counterion that is either a cation or ananion. Among the preferred cations (including cations as well ascompounds that can form cations) are aluminum, ammonium, benzathine,calcium, diethanolamine, diethylamine, dimeglumine, disodium, lithium,lysine, magnesium, meglumine, potassium, sodium, and zinc. Among thepreferred anions are acetate, L-aspartate, besylate, bicarbonate,carbonate, D-camsylate, L-camsylate, citrate, edisylate, fumarate,gluconate, hydrobromide/bromide, hydrochloride/chloride, D-lactate,L-lactate, DL-lactate, D,L-malate, L-malate, mesylate, pamoate,phosphate, succinate, sulfate, D-tartrate, L-tartrate, D,L-tartrate,meso-tartrate, benzoate, gluceptate, D-glucuronate, hybenzate,isethionate, malonate, methylsufate, 2-napsylate, nicotinate, nitrate,orotate, stearate, tosylate, acefyllinate, aceturate, aminosalicylate,ascorbate, ascorbate, borate, butyrate, camphorate, camphocarbonate,decanoate, hexanoate, cholate, cypionate, dichloroacetate, edentate,ethyl sulfate, furate, fusidate, galactarate (mucate), galacturonate,gallate, gentisate, glutamate, glutamate, glutarate, glycerophosphate,heptanoate (enanthate), hydroxybenzoate, hippurate, phenylpropionate,iodide, xinafoate, lactobionate, laurate, maleate, mandelate,methanesufonate, myristate, napadisilate, oleate, oxalate, palmitate,picrate, pivalate, propionate, pyrophosphate, salicylate,salicylsulfate, sulfosalicylate, sulfosalicylate, tannate,terephthalate, thiosalicylate, tribrophenate, valerate, valproate,adipate, 4-acetamidobenzoate, camsylate, octanoate, estolate, esylate,glycolate, thiocyanate, and undecylenate.

When a metal cation is employed as a counterion of the active agent, theinteraction between guest and cation is not a hydrogen bond but ratheris an intermolecular interaction between an electron rich group such asa carbonyl and the metal cation. This interaction is often not as strongas a hydrogen bond, but is still a favorable interaction and thus cancontribute to the stabilization of a cocrystal.

The HCl salt of an active pharmaceutical ingredient is especiallypreferred to create a new type of cocrystal. In this type of solid statephase, one can cocrystallize the HCl salt with a neutral guest molecule.By doing this one can create solid state phases with specificproperties. For instance one can make a solid comprising an activepharmaceutical ingredient having greater or lesser intrinsic solubilityand/or a faster or slower dissolution rate, depending on the guestcompound that is chosen.

Guests

The guest is present in order to form the cocrystal with the activeagent. It is contemplated that one or more guests may be employed in acocrystal, according to any of the present techniques. Accordingly, theguest is not required to have an activity of its own, although it mayhave some activity that does not overly derogate from the desiredactivity of the active agent. In some situations, the guest may have thesame activity as or an activity complementary to that of the activeagent. The guest may be another API. For example, some guests mayfacilitate the therapeutic effect of an active pharmaceuticalingredient. For pharmaceutical formulations, the guest may be anypharmaceutically acceptable molecule(s) that forms a cocrystal with theAPI or its salt. The RTECS database is a useful source for toxicologyinformation, and the GRAS list contains about 2500 relevant compounds.

The guest may be neutral (such as benzoic acid and succinic acid in theexamples below) or ionic (such as sodium benzoate or sodium succinate).Neutral guests are nonionic guests. Ionic guests are compounds orcomplexes having ionic bonds. FIG. 5 shows several general classes ofguests (organic bases, organic salts, alcohols & aldehydes, amino acids,sugars, ionic inorganics, aliphatic esters & ketones, organic acids, andaromatic esters & ketones).

The guest may be an acid that forms hydrogen bonds with the chloride (orother anion). For example, suitable guests which are acids include (butnot are not limited to):

-   ascorbic acid-   glucoheptonic acid-   sebacic acid-   alginic acid-   cyclamic acid-   ethane-1,2-disulfonic acid-   2-hydroxyethanesulfonic acid-   2-oxo-glutaric acid-   naphthalene-1,5-disulfonic acid-   nicotinic acid-   pyroglutamic acid-   4-acetamidobenzoic acid

Table 1 sets forth a group of presently preferred guests. It iscontemplated that the guests set forth in the Table may be arranged insubgroups based upon molecular structure and/or physiological effect.Furthermore, the foregoing list is intended to provide a writtendescription of any sublist that omits one or more guests.

Table 2 sets forth another group of preferred guests. It is contemplatedthat the guests set forth in the Table may be arranged in subgroupsbased upon molecular structure and/or physiological effect. Furthermore,the foregoing list is intended to provide a written description of anysublist that omits one or more guests.

Table 3 sets forth the group comprising molecules believed at present tobe suitable guests. It is contemplated that the guests set forth in theTable may be arranged in subgroups based upon molecular structure and/orphysiological effect. Furthermore, the foregoing list is intended toprovide a written description of any sublist that omits one or moreguests.

Ionic guests are salts themselves, and may be formed from bases andacids prior to being used to form cocrystals. For example, the followingbases and acids may be reacted to form ionic guests:

Bases

-   Ammonia-   L-Arginine-   Benethamine-   Benzathine-   Betaine-   Calcium Hydroxide-   Choline-   Deanol-   Diethanolamine-   Diethylamine-   2-(Diethylamino)ethanol-   2-Aminoethanol-   Ethylenediamine-   N-Methylglucamine-   Hydrabamine-   1H-Imidazole-   Lysine-   Magnesium Hydroxide-   Morpholine-   4-(2-Hydroxyethyl)Morpholine-   Piperazine-   Potassium Hydroxide-   Pyrrolidine-   1-(2-Hydroxyethyl)Pyrrolidine-   Sodium Hydroxide-   Triethanolamine-   Tromethamine-   Zinc Hydroxide

Acids

-   (+)-L-Tartaric Acid-   1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic Acid-   10-Undecylenic Acid-   1-Hydroxy-2-naphthoic Acid-   (+)-Camphor-10-sulfonic Acid-   2,5-Dihydroxybenzoic Acid-   2-Furancarboxylic Acid-   2-Mercaptobenzoic Acid-   3-Cyclopentylpropionic Acid-   3-Phenylpropionic Acid-   4-Aminosalicylic Acid-   4-Hydroxybenzoic Acid-   Acetic Acid-   Adipic Acid-   alpha-Hydroxypropionic Acid-   Benzenesulfonic Acid-   Benzoic Acid-   Carbonic Acid-   Cholic Acid-   Citric Acid-   (−)-D-Tartaric Acid-   (+)-D-Camphoric Acid-   (+)-D-Malic Acid-   (+)-L-Malic Acid-   2,2-Dichloroacetic Acid-   DL-10-Camphorsulfonic Acid-   DL-Glutamic Acid-   DL-Malic Acid-   DL-Tartaric Acid-   Dodecylsulfuric Acid-   Ethanesulfonic Acid-   Ethylenediaminetetraacetic Acid-   Ethylsulfuric Acid-   Fumaric Acid-   Galactaric Acid-   Gallic Acid-   Gluconic Acid-   Glutaric Acid-   Glycolic Acid-   Hippuric Acid-   Hydriodic Acid-   Hydrobromic Acid-   Hydrochloric Acid-   (−)-L-Apple Acid-   (+)-L-Lactic Acid-   (+)-L-Tartaric Acid-   D,L-Lactic Acid-   Lactobionic Acid-   L-Aspartic Acid-   Lauric Acid-   L-Glutamic Acid-   Maleic Acid-   (−)-L-Malic Acid-   Malonic Acid-   D,L-Mandelic Acid-   Methanesulfonic Acid-   Naphthalene-2-sulfonic acid-   n-Butyric Acid-   n-Decanoic Acid-   n-Hexanoic Acid-   Nitric acid-   n-Tetradecanoic Acid-   Octanoic Acid-   Oleic Acid-   Orotic Acid-   Orthoboric Acid-   Oxalic Acid-   4-Acetamidobenzoic Acid-   Palmitic Acid-   Pamoic Acid-   Phosphoric Acid-   Picric Acid-   Pivalic Acid-   Propionic Acid-   p-Toluenesulfonic Acid-   Pyrophosphoric Acid-   Salicylic Acid-   Stearic Acid-   Succinic Acid-   Sulfosalicylic Acid-   Sulfuric Acid-   Terephthalic Acid-   Thiocyanic Acid-   Valeric Acid-   Valproic Acid

Typically, suitable guests will have complementary ability tononcovalently bond to the active agent or its salt, for example theability to form hydrogen bonds with the active agent or its salt.Suitable guests for active agents having negative counterions include,but are not limited to, compounds having alcohol, ketone, ester, and/orcarboxylic acid functionalities. Suitable guests may include organicacids, organic bases, organic salts, alcohols, aldehydes, amino acids,sugars, ionic inorganic compounds, aliphatic esters and ketones, andaromatic esters and ketones.

Among the presently preferred neutral guests are those which are notliquids at room temperature. Also among the presently preferred neutralguests are carboxylic acids having at least three carbon atoms,alternatively at least four carbon atoms, and which do not formsolvates. For example, if the following acids were combined with activeagents, the combination would more properly be considered a solvate thana cocrystal: acetic acid, propionic acid, and butyric acid. However, incertain embodiments of the present invention (for example, in certaincocrystals, cocrystallization methods, and screening methods), the useof solvents and solvates may still be desirable, and the use of solventsand solvates is not excluded from the scope of any cocrystal or methodexcept where explicitly stated.

Detection of Cocrystals

Cocrystals may be detected by x-ray diffraction analysis or othersuitable techniques. The observation of physical properties of a solid(particularly its melting point) which differ from the physicalproperties of the starting materials and the polymorphs and/or solvatesand/or hydrates of the starting materials, is an indicator that acocrystal has been formed.

A method of crystal engineering is described. An active pharmaceuticalingredient such as fluoxetine hydrochloride is recognized as possessinga strong hydrogen bond acceptor. The API is screened against a libraryof strong hydrogen bond donors or other possible guest compounds. Such alibrary is selected and ordered based upon nontoxicity, physicalproperty, and the availability and geometric arrangement of hydrogenbond donors that are complementary to the API.

The results from a cocrystal screen of fluoxetine hydrochloridedemonstrate a new class of cocrystal that is broadly applicable to awide variety of hydrochloride salts of APIs. This new approach is ageneral method that allows creation of cocrystals starting with thehydrochloride salt of the API. Starting with the hydrochloride retainsthe advantages of the salt, yet one is still able to use the cocrystalmethod to alter the physical properties of the resulting solid by addingguest molecules.

Example 1 Cocrystallization of Fluoxetine HCl and Benzoic Acid

Cocrystals of fluoxetine HCl:benzoic acid were formed using thefollowing procedures. In one preparation, a 505 mg sample of fluoxetineHCl and 178 mg of benzoic acid were dissolved with heating in 5 mL ofacetonitrile. The solution was allowed to crystallize in a smallcrystallization dish. Well-formed crystalline material formed within 7minutes. This material was isolated on filter paper and dried in the airto yield 546 (80%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

In another preparation, a 5.00 g sample of fluoxetine HCl and 1.76 g ofbenzoic acid were dissolved in 50 mL of acetonitrile with heating. Thesolution was allowed to crystallize in a large evaporating dish. Theresulting solid was isolated on filter paper and dried in the air toyield 5.40 g (92%) of fluoxetine HCl:benzoic acid (1:1) cocrystal.

The cocrystal had a relatively slow dissolution rate and lower watersolubility. The measured melting point was 134° C.+/−2° C. for thecocrystal. The cocrystal is expected to have a good toxicology profile,since benzoic acid is known to be safe and appears on the GRAS list fromthe U.S. Food and Drug Administration.

The resulting cocrystal is a ternary system comprising the protonatedAPI base, the chloride ion, and the neutral guest molecule.

The present inventor believes there are no known solvates or hydrates offluoxetine hydrochloride. Thus, the formation of a cocrystal offluoxetine hydrochloride constitutes a surprising achievement andprovides a unique composition.

Example 2 Cocrystallization of Fluoxetine HCl and Succinic Acid

Cocrystals of fluoxetine HCl and succinic acid were prepared as follows.In one preparation, a 458 mg sample of fluoxetine HCl was dissolved in 8mL of acetonitrile by heating the solution gently. A 78 mg sample ofsuccinic acid was added to the warm solution and dissolved. The solutionwas allowed to evaporate rapidly in a crystallization dish. Well-formedcrystals as blocks formed as the solvent evaporated over 8 minutes. Theproduct was collected on filter paper and dried to yield 401 mg offluoxetine HCl:succinic acid (2:1) cocrystal (75% yield).

In another preparation, a 5.00 g sample of fluoxetine HCl and 0.85 g ofsuccinic acid were dissolved in acetonitrile with heating. The solutionwas allowed to crystallize in an open evaporating dish over a 15 minuteperiod. The solid material was isolated on filter paper and dried toyield 5.40 g (92% yield) of fluoxetine HCl:succinic acid (2:1)cocrystal.

The measured melting points were 158° C. for fluoxetine HCl, 184° C. forsuccinic acid, and 137° C. for the cocrystal. The cocrystal is expectedto have a good toxicology profile, since succinic acid is known to besafe and appears on the Generally Recognized As Safe (“GRAS”) list fromthe U.S. Food and Drug Administration.

Example 3 Cocrystallization of Nabumetone and 2,3-naphthalenediol

As a demonstrative example, a cocrystal comprising a neutral API isdescribed in this example. Cocrystals of nabumetone (a neutral API) and2,3-naphthalenediol were prepared as follows. A 4.01 g sample of2,3-naphthalenediol and 5.7 g of nabumetone were dissolved in 50 mL ofnitromethane with heating. A solid was formed as the solution cooled andwas allowed to stand overnight. The solid was filtered from theremaining solvent and dried in the air to yield 6.61 g (68%) ofnabumetone:2,3-naphthalenediol (1:1) cocrystal.

The resulting cocrystal had a 1:1 molar ratio of nabumetone to2,3-naphthalienediol. The measured melting points were 80° C. fornabumetone, 162° C. for 2,3-naphthalienediol, and 98° C. for thecocrystal. The cocrystal is expected to have a relatively poortoxicology profile. However, this example demonstrates one basis for theselection of guest molecules: molecular structural similarities. In thiscase the molecular recognition of the naphthalene moieties of the APIand the guest contribute to the stability of the cocrystal. In addition,the stronger alcohol to ketone hydrogen bonds formed by the cocrystalcontribute to the stability of the cocrystal. The only hydrogen bonddonors available in the API crystal structure are weak C-H groups. Thestronger hydrogen bond donors on the guest molecule are able to formstronger intermolecular interaction between the API and guest, comparedto the interactions between molecules of the API.

Example 4 Crystal Structure Analysis of Fluoxetine HCl:Benzoic AcidCocrystal (1:1)

A suitable cocrystal of fluoxetine HCl:benzoic acid (1:1) was coatedwith Paratone N oil, suspended in a small fiber loop and placed in acooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealedtube diffractometer with graphite monochromated MoK_(α) (0.71073 Å)radiation. Data were measured using a series of combinations of phi andomega scans with 10 second frame exposures and 0.3° frame widths. Datacollection, indexing and initial cell refinements were all carried outusing SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). Frame integration and final cell refinements were doneusing SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). The final cell parameters were determined fromleast-squares refinement on 5435 reflections. The SADABS program wasused to carry out absorption corrections (SADABS Version 2.03, 2001,George Sheldrick, University of Göttingen).

The structure was solved using Direct methods and difference Fouriertechniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-raySystems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogenatoms were placed their expected chemical positions using the HFIXcommand and were included in the final cycles of least squares withisotropic U_(ij)'s related to the atom's ridden upon. The C-H distanceswere fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å(methylene), or 0.96 Å (methyl); All non-hydrogen atoms were refinedanisotropically. Scattering factors and anomalous dispersion correctionsare taken from A. J. C. Wilson (ed), International Tables for X-rayCrystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992,Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). theInternational Tables for X-ray Crystallography. Structure solution,refinement, graphics and generation of publication materials wereperformed by using SHELXTL, V5.10 software. Additional details of datacollection and structure refinement are given in Table 4 which follows.

Example 5 Crystal Structure Analysis of Fluoxetine HCl:Succinic AcidCocrystal (2:1)

A suitable cocrystal of fluoxetine HCl-succinic acid (2:1) was coatedwith Paratone N oil, suspended in a small fiber loop and placed in acooled nitrogen gas stream at 100 K on a Bruker D8 SMART APEX CCD sealedtube diffractometer with graphite monochromated MoK_(α) (0.71073 Å)radiation. Data were measured using a series of combinations of phi andomega scans with 10 second frame exposures and 0.3° frame widths. Datacollection, indexing and initial cell refinements were all carried outusing SMART software (SMART Version 5.624, 2000, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). Frame integration and final cell refinements were doneusing SAINT software (SAINT Version 6.02, 2000, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). The final cell parameters were determined fromleast-squares refinement on 5435 reflections. The SADABS program wasused to carry out absorption corrections (SADABS Version 2.03, 2001,George Sheldrick, University of Göttingen).

The structure was solved using Direct methods and difference Fouriertechniques (SHELXTL V5.10, 2000, Bruker AXS, Inc., Analytical X-raySystems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogenatoms were placed their expected chemical positions using the HFIXcommand and were included in the final cycles of least squares withisotropic U_(ij)'s related to the atom's ridden upon. The C—H distanceswere fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å(methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refinedanisotropically. Scattering factors and anomalous dispersion correctionsare taken from A. J. C. Wilson (ed), International Tables for X-rayCrystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992,Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structuresolution, refinement, graphics and generation of publication materialswere performed by using SHELXTL, V5.10 software. Additional details ofdata collection and structure refinement are given in Table 5 whichfollows.

Example 6 Crystal Structure Analysis of Nabumetone:2,3-naphthalenediolCocrystal (1:1)

A suitable cocrystal of nabumetone:2,3-naphthalenediol (1:1) was coatedwith Paratone N oil, suspended in a small fiber loop and placed in acooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealedtube diffractometer with graphite monochromated CuK_(α) (1.54178 Å)radiation. Data were measured using a series of combinations of phi andomega scans with 10 second frame exposures and 0.3° frame widths. Datacollection, indexing and initial cell refinements were all carried outusing SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). Frame integration and final cell refinements were doneusing SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc.,Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis.53711-5373). The final cell parameters were determined fromleast-squares refinement on 2869 reflections.

The structure was solved using Direct methods and difference Fouriertechniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-raySystems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Hydrogenatoms were placed their expected chemical positions using the HFIXcommand and were included in the final cycles of least squares withisotropic U_(ij)'s related to the atom's ridden upon. The C-H distanceswere fixed at 0.93 Å (aromatic and amide), 0.98 Å (methine), 0.97 Å(methylene), or 0.96 Å (methyl). All non-hydrogen atoms were refinedanisotropically. Scattering factors and anomalous dispersion correctionsare taken from A. J. C. Wilson (ed), International Tables for X-rayCrystallography, Volume C. Kynoch, Academic Publishers, Dordrecht, 1992,Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222). Structuresolution, refinement, graphics and generation of publication materialswere performed by using SHELXTL, V5.10 software. Additional details ofdata collection and structure refinement are given in Table 6 whichfollows.

Example 7 Cocrystals of Active Agent Salts and Guests

The experiments of Examples 1 and 2 are repeated, using conditionssimilar to those of those previous Examples, with each possiblecombination of the salts of active agents and guests identified earlierin this disclosure. Cocrystals are formed which have utility accordingto the known activity of the active agent.

Example 8 Cocrystals of Active Agents and Guest Salts

The experiments of Example 3 are repeated, using conditions similar tothose of those previous Examples, with each possible combination of theneutral or zwitterionic active agents and guest salts identified earlierin this disclosure. Cocrystals are formed which have utility accordingto the known activity of the active agent.

Example 9 Cocrystallization of Fluoxetine HCl and Fumaric Acid

Cocrystals of fluoxetine HCl and succinic acid were prepared as follows.A 6.00 g sample of fluoxetine HCl and 1.01 g of fumaric acid weredissolved in 20 mL of ethanol with heating. The solution was filteredthrough a 0.2 μm nylon filter, concentrated to a volume of 8 mL, andcooled in an ice bath for 6 hours. The solid material was isolated onfilter paper and allowed to dry in the air to give 5.74 g (82% yield) offluoxetine HCl:fumaric acid (2:1) cocrystal. The measured melting pointswere 158° C. for fluoxetine HCl, >300° C. (decomposes) for fumaric acid,and 164° C. for the cocrystal. The cocrystal is expected to have a goodtoxicology profile, since fumaric acid is known to be safe and appearson the Generally Recognized As Safe (“GRAS”) list from the U.S. Food andDrug Administration.

Example 10 Crystal Structure Analysis of Fluoxetine HCl:Fumaric AcidCocrystal (2:1)

A suitable cocrystal of fluoxetine HCl and fumaric acid was coated withParatone N oil, suspended in a small fiber loop and placed in a coolednitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tubediffractometer with graphite monochromated CuKa (1.54178 Å) radiation.Data were measured using a series of combinations of phi and omega scanswith 10 second frame exposures and 0.30 frame widths. Data collection,indexing and initial cell refinements were all carried out using SMARTsoftware (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-raySystems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frameintegration and final cell refinements were done using SAINT software(SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems,5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cellparameters were determined from least-squares refinement on 5625reflections.

The structure was solved using Direct methods and difference Fouriertechniques (SHELXTL V5.10, 1997, Bruker AXS, Inc., Analytical X-raySystems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). All thehydrogen atoms were located from difference Fouriers and included in thefinal cycles of least squares with isotropic Uij's. All non-hydrogenatoms were refined anisotropically. Scattering factors and anomalousdispersion corrections are taken from A. J. C. Wilson (ed),International Tables for X-ray Crystallography, Volume C. Kynoch,Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and4.2.6.8 (pp. 219-222). Structure solution, refinement, graphics andgeneration of publication materials were performed by using SHELXTL,V5.10 software. Additional details of data collection and structurerefinement are given in Table G which follows.

All patents, test procedures, and other documents cited herein,including priority documents, are fully incorporated by reference to theextent such disclosure is not inconsistent with this invention and forall jurisdictions in which such incorporation is permitted.

While the present invention has been described and illustrated byreference to particular embodiments, it will be appreciated by those ofordinary skill in the art that the invention lends itself to manydifferent variations not illustrated herein. For these reasons, then,reference should be made solely to the appended claims for purposes ofdetermining the true scope of the present invention.

Although the appendant claims have single appendencies in accordancewith U.S. patent practice, each of the features in any of the appendantclaims can be combined with each of the features of other appendantclaims or the main claim.

TABLE 1 10-camphorsulfonic acid 10-undecylenic acid1-hydroxy-2-naphthoic acid 2,4-dihydroxybenzoic acid2,5-dihydroxybenzoic acid 2-aminopropionic acid 2-ethylbutyrinc acid2-furancarboxylic acid 2-mercaptobenzoic acid 3-methylbutanoic acid3-phenylpropionic acid 4-aminobenzoic acid 4-aminosalicylic acid4-hydroxybenzoic acid adipic acid alginic acid anisic acid arginineascorbic acid asparagine aspartic acid aspirin benzenesulfonic acidbenzoic acid 4-acetamidobenzoic acid beta-alanine camphoric acidcamphorsulfonic acid carbonic acid cholic acid cinnamic acid citric acidcyclamic acid cyclohexanecarboxylic acid cyclohexylacetic acid cysteinediphenylacetic acid dodecylsulfonic acid ethane-1,2-disulfonic acidethanesulfonic acid ethanesulfonic acid, 2-hydroxyethylenediaminetetraacetic acid ethylsulfuric acid fumaric acidgalactaric acid gallic acid gentisic acid glucoheptonic acid gluconicacid glutamic Acid glutamine glutaric acid glutaric acid, 2-oxo- glycineglycolic acid hippuric acid histidine hydroxyproline isoleucinelactobionic acid lauric acid leucine levulinic acid lysine maleic acidmalic acid malonic acid mandelic acid m-methoxybenzoic acidnaphthalene-1,5-disulfonic acid naphthalene-2-sulfonic acid n-decanoicacid niacin nicotinic acid n-tetradecanoic acid oleic acido-methylbenzoic acid orotic acid orthoboric acid o-toluic acidp-acetamidobenzoic acid palmitic acid pamoic acid phenoxyacetic acidphenylacetic acid phenylalanine picric acid pivalic acid prolinep-toluenesulfonic acid pyroglutamic acid pyruvic acid salicylic acidsebacic acid serine sorbic acid stearic acid succinic acidsulfosalicylic acid tartaric acid terephthalic acid thiocyanic acidthreonine tiglic acid tryptophan tyrosine valeric acid valine

Name CAS # Potassium bicarbonate 298-14-6 Potassium carbonate 584-08-7Potassium chloride 7447-40-7 Potassium hydroxide 1310-58-3 Potassiummetabisulfite 16731-55-8 Potassium nitrate 7757-79-1 Potassium nitrite7758-09-0 Potassium permanganate 7722-64-7 Potassium persulfate7727-21-1 Potassium phosphate, dibasic 2139900 Potassium PhosphateMonobasic 7778-77-0 potassium phosphate, tribasic, 7778-53-2 n-hydratePotassium sulfate 7778-80-5 Sodium bicarbonate 144-55-8 Sodium bisulfite7631-90-5 Sodium borohydride 16940-66-2 Sodium carbonate 497-19-8 SodiumCarbonate Monohydrate 1486118 Sodium chloride 7647-14-5 Sodiumdithionite 7775-14-6 Sodium fluoride 7681-49-4 Sodium hexametaphosphate10124-56-8 Sodium hydroxide 1310-73-2 Sodium hypochlorite 7681-52-9Sodium Metabisulfite 7681-57-4 Disodium metasilicate 6834-92-0 sodiummonophosphate 7681-53-0 Sodium nitrate 7631-99-4 Sodium nitrite7632-00-0 sodium hydrogen phosphate 7558-79-4 Sodium Phosphate Monobasic7558-80-7 Sodium Pyrophosphate 7722-88-5 Sodium silicate 1344-09-8Sodium Sulfate Decahydrate 7727-73-3 Sodium sulfite 7757-83-7 SodiumThiosulfate 10102-17-7 Pentahydrate Calcium acetate 5743-26-0 CalciumCarbonate 471-34-1 Calcium Chloride Dihydrate 10035-04-8 Calciumgluconate 299-28-5 Calcium hydroxide 1305-62-0 Calcium oxide 1305-78-8Calcium phosphate, dibasic 7757-93-9 Calcium Phosphate Monobasic7758-23-8 Calcium sulfate 7778-18-9 Magnesium hydroxide 1309-42-8Magnesium Sulfate Heptahydrate 10034-99-8 Aluminum 7429-90-5 Aluminumammonium sulfate 7784-26-1 Aluminum chloride 7446-70-0 Aluminumhydroxide 21645-51-2 Aluminum potassium sulfate, 7784-24-9 dodecahydrateOrthoboric acid 10043-35-3 formaldehyde 50-00-0 DL-Isoleucine 443-79-8(2S,7S)-(−)-Cystine 56-89-3 DL-Alanine 302-72-7 beta-Alanine 107-95-9(S)-(+)-Arginine 74-79-3 (S)-(−)-Cysteine 52-90-4 DL-Glutamic acid617-65-2 Glycine 56-40-6 (S)-(−)-Histidine 71-00-1 (S)-(+)-Lysine56-87-1 DL-Methionine 59-51-8 DL-Phenylalanine 150-30-1(S)-(−)-Phenylalanine 63-91-2 D-(+)-Proline 344-25-2 (S)-(−)-Tryptophan73-22-3 (S)-(−)-Tyrosine 60-18-4 Carvone 99-49-0 Citral 5392-40-5 Ethylbutyrate 105-54-4 Isobutyl propionate 540-42-1 Methyl butyrate 623-42-7n-Propyl acetate 109-60-4 Isobutyl formate 542-55-2 Benzyl acetate140-11-4 6-Methyl-5-hepten-2-one 110-93-0 Butyl acetate 123-86-4 Ethylacetoacetate 141-97-9 Isopentyl Acetate 123-92-2 Cinnamaldehyde 104-55-2Methyl benzoate 93-58-3 Butyl sulfide 544-40-1 Ethyl benzoate 93-89-02,4-Hexadienoic acid, 24634-61-5 potassium salt, (E,E)- Potassiumbitartrate 868-14-4 Lauric acid 143-07-7 Benzyl benzoate 120-51-4 Picricacid 88-89-1 Benzoyl peroxide 94-36-0 Palmitic acid 57-10-3 Dibutylphthalate 84-74-2 Stearic acid 57-11-4 Succinic anhydride 108-30-5Diethylenetriamine 111-40-0 Diethanolamine 111-42-2 Benzaldehyde100-52-7 Phenethylamine 64-04-0 Salicylylaldehyde 90-02-8 Sodiumbenzoate 532-32-1 Cinnamic acid 621-82-9 Triethanolamine 102-71-6L-(+)-Tartaric Acid 87-69-4 Eugenol 97-53-0 D-mannitol 69-65-8 Butylparaben 94-26-8 Benzoin 119-53-9 Diethyl phthalate 84-66-2 Oleic acid112-80-1 Sodium lactate 72-17-3 Indole 120-72-9 ethyl lactate 97-64-3quinoline 91-22-5 Thymol 89-83-8 Methyl anthranilate 134-20-3 Methylsalicylate 119-36-8 Diethyl malonate 105-53-3 Citric acid 77-92-9 Sodiumdodecyl sulfate 151-21-3 Morpholine 110-91-8 Furfural 98-01-1 Niacin59-67-6 Choline chloride 67-48-1 L-Menthol 2216-51-5 Meso-inositol87-89-8 ethylenediaminetetraacetic 60-00-4 acid EDTA, calciumderivative, 62-33-9 disodium salt Calcium pantothenate 137-08-6Riboflavin 83-88-5 Zinc carbonate 3486-35-9 Amyl alcohol 71-41-0 Mineraloil 8012-95-1 Triton(R) X-100 9002-93-1 Acetaldehyde 75-07-0 Acetic Acid64-19-7 Acetone 67-64-1 Acetophenone 98-86-2 4-Aminobenzoic acid150-13-0 Anisole 100-66-3 Vitamin C 50-81-7 Benzoic Acid 65-85-0Biphenyl 92-52-4 2-Methyl-1-propanol 78-83-1 n-Butanol 71-36-3n-Butylamine 109-73-9 ethyl acetate 141-78-6 Caffeine 58-08-2Chloroacetic Acid 79-11-8 Dichloroacetic Acid 79-43-6 Diethylamine109-89-7 Ethanol Amine 141-43-5 n-Butyric Acid 107-92-6 Ethylenediamine107-15-3 Formic acid 64-18-6 n-Hexanol 111-27-3 Methanol 67-56-1 MethylAcetate 79-20-9 Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4p-Cresol 106-44-5 Phenol 108-95-2 n-Propanol 71-23-8 Propionic Acid79-09-4 Salicylic acid 69-72-7 Sucrose 57-50-1 Vanillin 121-33-5 VitaminE 59-02-9 Potassium citrate, monohydrate 1534146 p-toluenesulfonic acid6192-52-5 monohydrate D-(+)-Maltose 69-79-4 Tetrasodium 64-02-8ethylenediaminetetraacetate Saccharin sodium 128-44-9 Sodium AcetateTrihydrate 6131-90-4 Quinine sulfate, dihydrate 6119-70-6 Sulfosalicylicacid, dihydrate 5965-83-3 L-(+)-Arginine 1119-34-2 monohydrochlorideProcaine hydrochloride 51-05-8 Pyridoxine Hydrochloride 58-56-0 Thiaminehydrochloride 67-03-8 Propionaldehyde 123-38-6 Urea 57-13-6 2-Propanol67-63-0 Pyrrole 109-97-7 Sodium formate 141-53-7 Pyrrolidine 123-75-1Methyl ethyl ketone 78-93-3 Ethyl formate 109-94-4 Propylene glycol57-55-6 Thiourea 62-56-6 Ammonium acetate 631-61-8 Benzene 71-43-2Sodium acetate 127-09-3 Cyclopentanone 120-92-3 Cyclohexane 110-82-7piperidine 110-89-4 2-Pentanone 107-87-9 hexane 110-54-3 Isoamyl Alcohol123-51-3 Lactic acid 50-21-5 2-Ethoxyethanol 110-80-5 Propionic acid,sodium salt 137-40-6 Potassium acetate 127-08-2 cyclohexyl amine108-91-8 methyl methacrylate 80-62-6 methyl isobutyl ketone 108-10-1Acetic anhydride 108-24-7 Isopropyl Acetate 108-21-4 2,2′-Oxybisethanol111-46-6 Benzyl alcohol 100-51-6 Resorcinol 108-46-3 2-Butoxy ethanol111-76-2 Cumene 98-82-8 2-Amino-2-(hydroxymethyl)-1,3- 77-86-1propanediol Phenethyl alcohol 60-12-8 2-Ethyl-1-hexanol 104-76-72-Octanol 123-96-6 2-(2-Ethoxyethoxy)ethanol 111-90-02,6-Dimethyl-4-heptanone 108-83-8 Benzophenone 119-61-9 D-(−)-Fructose57-48-7 D-Glucose 50-99-7 D-Ribose 50-69-1 D-(+)-Xylose 58-86-6 Pectinsugar 5328-37-0 D-(+)-Lactose 63-42-3 Camphene 79-92-5 Isoquinoline119-65-3 2,4-Dimethylphenol 105-67-9 2,5-Dimethylphenol 95-87-42,6-Dimethylphenol 576-26-1 Methanesulfonic Acid 75-75-2o-Methoxybenzoic Acid 579-75-9 Saccharin 81-07-2 Thiazole 288-47-1Trifluoromethanesulfonic Acid 1493-13-6 Trimethylamine 75-50-3 Coumarin91-64-5 Dimethylamine 124-40-3 Ethyl Alcohol 64-17-5 Butyl benzylphthalate 85-68-7 2,6-dimethylpyrazine 108-50-9 taurocholic acid 81-24-3geraniol 106-24-1 linalool 78-70-6 ethyl isovalerate 108-64-5 ethyl2-methylbutyrate 7452-79-1 1-octen-3-ol 3391-86-4 ethyl 2-trans-4-cis-3025-30-7 decadienoate Dihydromyrcenol 18479-58-8 citronellal 106-23-0linalyl acetate 115-95-7 8-mercapto-p-menthan-3-one 38462-22-5 Ammoniumcitrate 3012-65-5 Ammonium bicarbonate 1066-33-7 Ammonium chloride12125-02-9 Ammonium hydroxide 1336-21-6 Ammonium persulfate 7727-54-0Ammonium phosphate, dibasic 7783-28-0 Ammonium Phosphate Monobasic7722-76-1 Ammonium sulfate 7783-20-2 Ammonium sulfide 12135-76-1Hydrazine 302-01-2 Nitric acid 7697-37-2 phosphoric acid 7664-38-2Phosphorus oxychloride 10025-87-3 Hydriodic acid 10034-85-2 Hydrobromicacid 10035-10-6 Hydrochloric acid 7647-01-0 hydrogen peroxide 7722-84-1Periodic Acid 10450-60-9 Sulfamic acid 5329-14-6 Sulfuric acid 7664-93-9Sulfurous acid 7782-99-2 Dexpanthenol 81-13-0 4-oxoisophorone 1125-21-9Copper(II) sulfate 7758-98-7 ferric chloride 7705-08-0 Ferric oxide1309-37-1 ferric sulfate 10028-22-5 Iron(II)Sulfate Heptahydrate7782-63-0 Iron 7439-89-6 Manganese (II) Sulfate 10034-96-5 MonohydrateNickel 7440-02-0 Titanium dioxide 13463-67-7 Zinc chloride 7646-85-7Zinc oxide 1314-13-2 1,1′-Azobisformamide 123-77-3 1,3-Butanediol107-88-0 1-Methylnaphthalene 90-12-0 2,6-Di-tert-Butyl-p-Cresol 128-37-02,6-Dimethylpyridine 108-48-5 Disodium 138-93-2cyanodithioimidocarbonate 3-Methyl-2-Cyclopentene-2-ol- 80-71-7 one6-Methylcoumarin 92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2alpha-Terpinene 99-86-5 Benzenesulfonic Acid 98-11-3 Benzothiazole95-16-9 borates, tetrasodium salts 1330-43-4 Butyl butyrate 109-21-7Butyl Mercaptan 109-79-5 Butyraldehyde 123-72-8 Capsaicin 404-86-4Chloromethyl Methyl Ether 107-30-2 Cymene 99-87-6 Diallyl Disulfide2179-57-9 Diethylaminoethanol 100-37-8 dimethyldisulfide 624-92-0Dimethyl Succinate 106-65-0 Dimethyl Sulfate 77-78-1 Dimethyl Sulfide75-18-3 Dipropyl Disulfide 629-19-6 Dipropyl Ketone 123-19-3 EthylAcrylate 140-88-5 Ethyl Butyl Ketone 106-35-4 Ethyl Propionate 105-37-3Furfuryl Alcohol 98-00-0 gamma-Butyrolactone 96-48-0 Glutaraldehyde111-30-8 glycerin 56-81-5 Glycolic Acid 79-14-1 Isobutyl Acetate110-19-0 Isobutyl Isobutyrate 97-85-8 Isobutyraldehyde 78-84-2Isoheptanol 543-49-7 Isophorone 78-59-1 Isopropyl Mercaptan 75-33-2Methyl isobutenyl ketone 141-79-7 Methyl n-amyl ketone 110-43-0 methylacrylate 96-33-3 Methyl Isobutyrate 547-63-7 Methyl Mercaptan 74-93-1N,N-Dimethylethanolamine 108-01-0 n-Butyl Lactate 138-22-7 n-HexylAcetate 142-92-7 n-Valeraldehyde 110-62-3 Nitrous Oxide 10024-97-2p-Anisaldehyde 123-11-5 2-Methylcyclohexanone 583-60-8 Octanoic Acid124-07-2 Oxalic Acid 144-62-7 Phenyl ether 101-84-8 Phenylmercaptan108-98-5 Propargyl Alcohol 107-19-7 Propyl paraben 94-13-3 sec-ButylAlcohol 78-92-2 Sodium Gluconate 527-07-1 Sodium Tripolyphosphate7758-29-4 Tetrahydro-2-furanmethanol 97-99-4 Valeric Acid 109-52-43,4-xylenol 95-65-8 3-hexanol 623-37-0 3-methyl-1-pentanol 589-35-51,1-diethoxyethane 105-57-7 Aluminum Sulfate 10043-01-3 ammonium sulfite10196-04-0 amyl butyrate 540-18-1 borneol 507-70-0 butyl formate592-84-7 calcium peroxide 1305-79-9 n-Hexanoic Acid 142-62-1 cyclohexylacetate 622-45-7 diacetyl 431-03-8 dimethyl carbonate 616-38-6 ethylbutyraldehyde 97-96-1 Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1ethyl nitrite 109-95-5 fumaric acid 110-17-8 hexaldehyde 66-25-1isobutyric acid 79-31-2 methyl isovalerate 556-24-1 methyl propionate554-12-1 methyl valeraldehyde 123-15-9 nitrosyl chloride 2696-92-6octafluorocyclobutane 115-25-3 peroxyacetic acid 79-21-0 propyl formate110-74-7 propyl mercaptan 107-03-9 Sodium aluminate 1302-42-7 sodiumchlorite 7758-19-2 Terephthalic Acid 100-21-0 allyl isothiocyanate57-06-7 Vitamin B1 59-43-8 Valproic acid 99-66-1 Ethoxyquin 91-53-2n-Amyl Ethyl Ketone 106-68-3 Nabam 142-59-6 Sodium sulfide 1313-82-2Thiocyanic acid 463-56-9 2-Methyl-5-(1-methylethenyl)- 2244-16-82-cyclohexene-1-one 4-(2,6,6-Trimethyl-2- 127-41-3cyclohexen-1-yl)-3-buten-2-one 4-(2,6,6-trimethyl-1- 14901-07-6cyclohexen-1-yl)-3-buten-2-one Isoamyl propionate 105-68-03-Methylbutanoic acid 503-74-2 L-Menthone 14073-97-3 4-Ethylphenol123-07-9 o-cresol 95-48-7 dimethyl-Carbamodithioic acid, 128-04-1 sodiumsalt Anethole 104-46-1 Dimethyl terephthalate 120-61-6 propyl gallate121-79-9 L-Ascorbic Acid Sodium Salt 134-03-2 4-Hexylresorcinol 136-77-6Estragole 140-67-0 L-monosodium glutamate 142-47-2 Malonaldehyde, sodiumsalt 24382-04-5 Butylated hydroxyanisole 25013-16-5 allyl3-methylbutyrate 2835-39-4 DL-monosodium glutamate 32221-81-13-Acetyl-6-methyl-2,4- 520-45-6 pyrandione L-Glutamic Acid 56-86-0DL-alpha-tocopheryl acetate 58-95-7 D-limonene 5989-27-5 Calcium Acetate62-54-4 Erythorbic Acid Monosodium 6381-77-7 Salt Ethylmethylphenylglycidate 77-83-8 2,4,6-Trinitro-1,3-dimethyl-5- 81-15-2tert-butylbenzene Dimethoxane 828-00-2 3,5-Di-tert-butyl-4- 88-26-6hydroxybenzyl alcohol 6-Methylquinoline 91-62-3 alpha-Methylbenzylalcohol 98-85-1 Nicotinamide 98-92-0 3,4-Dihydrocoumarin 119-84-6Geranyl Acetate 105-87-3 Sodium (2-Ethylhexyl)Alcohol 126-92-1 SulfateCyclohexanol, 5-methyl-2-(1- 89-78-1 methylethyl)-,(1alpha,2beta,5alpha)- (+)-Camphor 464-49-3 (1S)-(−)-alpha-Pinene7785-26-4 1,3-Dihydroxy-5-methylbenzene 504-15-41,5-Naphthalenedisulfonic Acid 1655-29-4 Disodium Salt1-Hydroxy-2-naphthoic Acid 86-48-6 1-Penten-3-ol 616-25-11-Phenyl-1-propanol 93-54-9 10-Undecylenic Acid 112-38-92′-Hydroxyacetophenone 118-93-4 2,4-Dihydroxybenzoic Acid 89-86-12-Acetylfuran 1192-62-7 2-Furancarboxylic Acid 88-14-2 2-Isopropylphenol88-69-7 2-Ketoglutaric Acid 328-50-7 2-Ketovaline 759-05-72-n-Propylphenol 644-35-9 2-Naphthalenethiol 91-60-1 2-Phenyl-1-propanol1123-85-9 3,3′-Thiodipropionic Acid 111-17-1 3,5,5-Trimethylhexanal5435-64-3 3-Phenyl-1-propanol 122-97-4 3-Phenylpropionic Acid 501-52-04-Aminosalicylic Acid 65-49-6 4-Ethoxyphenol 622-62-8 4-HydroxybenzoicAcid 99-96-7 4-Phenyl-2-butanol 2344-70-9 4-tert-Octylphenol 140-66-9Allyl Cinnamate 1866-31-5 Allyl Mercaptan 870-23-5 alpha-L-Rhamnose3615-41-6 Alpha-Terpineol 98-55-5 Anisic Acid 100-09-4 Benzalacetone122-57-6 Benzaldehyde Dimethylacetal 1125-88-8 Benzyl Ether 103-50-4Benzyl Formate 104-57-4 Benzyl Mercaptan 100-53-8 Benzyl Salicylate118-58-1 Calcium Citrate 813-94-5 Calcium Glycerophosphate 27214-00-2Calcium Hypophosphite 7789-79-9 Calcium Iodate 7789-80-2 Propanoic acid,2-hydroxy-, 814-80-2 calcium salt (2:1) Calcium Phosphate Tribasic7758-87-4 Calcium Propionate 4075-81-4 Calcium Pyrophosphate 7790-76-3Cholic Acid 81-25-4 Choline 123-41-1 Choline Bitartrate 87-67-2trans-Cinnamic Aldehyde 14371-10-9 Cinnamyl Alcohol 104-54-1 Citronellol106-22-9 Copper(I)Iodide 7681-65-4 D-(+)-Glucono-1,5-lactone 90-80-2D-(−)-Tartaric Acid 147-71-7 D-Isoascorbic Acid 89-65-6 D-Tyrosine556-02-5 Sodium dehydroacetate 4418-26-2 Deoxycholic Acid 83-44-3Dibenzyl Ketone 102-04-5 Diethyl L-(+)-Tartrate 87-91-2 DiethylSuccinate 123-25-1 Dimethylacetal 534-15-6 DL-Cystine 923-32-0DL-Proline 609-36-9 DL-Tartaric Acid 133-37-9 DL-Tyrosine 556-03-6DL-Valine 516-06-3 Enanthoic Acid 111-14-8 Erythorbic Acid Sodium Salt7378-23-6 Ethyl 2-Aminobenzoate 87-25-2 Ethyl Cinnamate 103-36-6 Ethyln-Valerate 539-82-2 Ethyl Phenylacetate 101-97-3 Ethyl Salicylate118-61-6 Ethyl Sulfide 352-93-2 Ethyl Vanillin 121-32-4 EthyleneMercaptan 540-63-6 Farnesene 502-61-4 Folic acid 59-30-3gamma-Nonanolactone 104-61-0 gamma-Valerolactone 108-29-2 Gluconic Acid526-95-4 Gluconic Acid Potassium Salt 299-27-4 Glutaric Acid 110-94-1Guanosine-5′-monophosphate, 1333479 disodium salt Heliotropine 120-57-0Hippuric Acid 495-69-2 Hydroquinone Dimethyl Ether 150-78-7Inosine-5′-monophosphate 4691-65-0 Sodium Salt iso-Amyl Mercaptan541-31-1 Isoamyl Salicylate 87-20-7 iso-Butyl n-Hexanoate 105-79-3isovaleraldehyde 590-86-3 Isoamyl Benzoate 94-46-2 Isoamyl Formate110-45-2 Isoamyl n-Butyrate 106-27-4 Isoamylamine 107-85-7 Isobutyln-Butyrate 539-90-2 Isocaproic Acid 646-07-1 Isoeugenol 97-54-1Isopropyl Benzoate 939-48-0 Isopropyl Formate 625-55-8 IsopropylN-Butyrate 638-11-9 Isopropyl Propionate 637-78-5 isobutyl Mercaptan513-44-0 L-(+)-Isoleucine 73-32-5 L-(−)-Apple Acid 97-67-6L-2-Aminopropionic Acid 56-41-7 L-Aspartic acid 56-84-8 L-Carnitine541-15-1 L-Cysteine Hydrochloride 52-89-1 L-Glutamic Acid Hydrochloride138-15-8 L-Glutamine 56-85-9 L-Hydroxyproline 51-35-4 L-Proline 147-85-3L-Serine 56-45-1 L-Threonine 72-19-5 L-Valine 72-18-4 N-Acetylglycine543-24-8 n-Amyl Formate 638-49-3 n-Amyl n-Caproate 540-07-8 n-Butyln-Caproate 626-82-4 n-Butyl Propionate 590-01-2 n-Butyl Salicylate2052-14-4 n-Decanoic Acid 334-48-5 n-Hexyl Mercaptan 111-31-9 n-PropylBenzoate 2315-68-6 n-Propyl Isobutyrate 644-49-5 n-Tetradecanoic Acid544-63-8 Nitrilotriacetic Acid 5064-31-3 Trisodium Salt o-Toluenethiol137-06-4 Orotic Acid 65-86-1 p-Acetamidobenzoic Acid 556-08-1 p-AniseAlcohol 105-13-5 Phenoxyacetic Acid 122-59-8 Phenyl Acetate 122-79-2Piperine 94-62-2 Pivalic Acid 75-98-9 Potassium Benzoate 582-25-2Potassium Diphosphate 7320-34-5 Potassium Hypophosphite 7782-87-8Potassium Metaphosphate 7790-53-6 Potassium Sulfite 10117-38-1 QuinineHydrochloride 130-89-2 sec-Amyl Alcohol 6032-29-7 Sodium D-Pantothenate867-81-2 Di(2-ethylhexyl) sulfosuccinic 577-11-7 acid, sodium saltSodium Sorbate 7757-81-5 Succinic acid, disodium salt 150-90-3 SodiumTaurocholate 145-42-6 Taurine 107-35-7 Thiamine Nitrate 532-43-4Thioanisole 100-68-5 Tiglic Acid 80-59-1 Tri-n-butyrin 60-01-5 Triacetin102-76-1 Trisodium Citrate 68-04-2 Veratraldehyde 120-14-9 Veratrole91-16-7 Vitamin P 520-26-3 Vitamin U Chloride 582174 L-methionine63-68-3 2-Chloro-1-propanol 78-89-7 2-Ethylbutyric acid 88-09-52-Methylbutyraldehyde 96-17-3 2-Methyl-5-ethylpyridine 104-90-5 n-propylbutyrate 105-66-8 Ethyl caprylate 106-32-1 Propyl propionate 106-36-52-Methylpyrazine 109-08-0 3,3,5-Trimethyl-1-cyclohexanol 116-02-9 Ethylcaproate 123-66-0 o-methoxybenzaldehyde 135-02-4 2,4-Hexadienal 142-83-63-Hexanone 589-38-8 3-Methyl-2-butanol 598-75-4 Methyl isopropenylketone 814-78-8 3-Methyl-2-butanethiol 2084-18-6 3,5,5-Trimethylhexanol3452-97-9 Methylglyoxal 78-98-8 Malonaldehyde 542-78-9 1,4-Dithiane505-29-3 Amylcinnamaldehyde 122-40-7 Benzyl cinnamate 103-41-3tert-Butylhydroquinone 1948-33-0 Fusidic Acid Sodium Salt 751-94-0Hydroxycitronellal 107-75-5 Musk ketone 81-14-1 L-Asparagine 70-47-3phenethyl acetate 103-45-7 Riboflavin-5-Phosphate 146-17-8 PotassiumSodium Tartrate 304-59-6 Galactaric acid 526-99-8 Sodium Tartrate868-18-8 trisodium phosphate 7601-54-9 Disodium Pytophosphate 7758-16-9Magnesium chloride 7786-30-3 Sodium Polymethacrylate 54193-36-1propiophenone 93-55-0 2-ethylhexanoic acid 149-57-5 3,7,7-trimethylbicyclohep-3- 13466-78-9 ene 2,6-dimethyl-4-heptanol 108-82-75-isopropyl-2-methyl-phenol 499-75-2 L-Bornyl acetate 5655-61-8caryophyllene 87-44-5 hydroxymethylpyrone 118-71-8 neosperidindihydrochalcone 20702-77-6 2,2-Dibromo-3- 10222-01-2 nitrilopropionamideXylitol 87-99-0 Sulfosalicylic acid 97-05-2 Riboflavin 5′-(dihydrogen130-40-5 phosphate), monosodium salt Ethylenediaminetetraacetic 139-33-3acid, disodium salt Gallic acid 149-91-7 Carbonic acid 463-79-6Potassium carbonate, 6381-79-9 sesquihydrate Magnesium phosphatetribasic 7757-87-1 diallyl sulfide 592-88-1 ethyl 4-oxopentanoate539-88-8 methyl caproate 106-70-7 isopropyl isobutyrate 617-50-5 diethylhydroxybutanedioate 2065419 propyl isopentanoate 557-00-6 benzyl ethylether 539-30-0 isobutyl isopentanoate 589-59-3 propyl hexanoate 626-77-74-methylquinoline 491-35-0 methyl cinnamate 103-26-4 cumic alcohol536-60-7 thujone 471-15-8 dihydrocarveol 619-01-2 fenchyl alcohol1632-73-1 Nerol 106-25-2 isopentyl isopentanoate 659-70-1 methyleugenol93-15-2 methyl 2-naphthyl ketone 93-08-3 diphenyldisulfide 882-33-7citronellyl acetate 150-84-5 menthyl acetate 89-48-5 menthyl isovalerate16409-46-4 5-Ethyl-3-hydroxy-4-methyl- 698-10-2 2(5H)-furanone malicacid 6915-15-7 3-methylbutanoic acid butyl 109-19-3 ester3-phenyloxiranecarboxylic acid 121-39-1 ethyl ester1,2-Benzisothiazol-3(2H)-one 6381-61-9 1,1-dioxide, ammonium salt1-methyl-4-(1-methylethyl)- 99-85-4 1,4-Cyclohexadiene3-mercapto-2-Butanol 54812-86-1 (1R)-2,6,6- 7785-70-8trimethylbicyclo[3.1.1]hept-2- ene (1S)-6,6-dimethyl-2- 18172-67-3methylenebicyclo[3.1.1]heptane 1-methyl-4-(1- 586-62-9methylethylidene)cyclohexene 1-(3-pyridinyl)ethanone 350-03-81-pyrazinylethanone 22047-25-2 1-(2-furyl)-2-propanone 6975-60-61-Penten-3-one 1629-58-9 2,3-pentanedione 600-14-6 2,5-dimethylpyrazine123-32-0 2-isobutyl-3-methoxypyrazine 24683-00-94-methyl-2,3-pentanedione 7493-58-5 5-methylfurfural 620-02-0Dimethyltrisulfide 3658-80-8 furfuryl acetate 623-17-6furfurylmethylether 13679-46-4 terpinen-4-ol 562-74-3 Calcium sorbate7492-55-9 Potassium lactate 996-31-6 1-Hydroxyethylidene-1,1- 2809-21-4diphosphonic acid L-glutamic acid monopotassium 19473-49-5 salt3-methyl-2-buten-1-ol 556-82-1 phenylethanal 122-78-14′-Methoxyacetophenone 100-06-1 L-borneol 464-45-9 2,4-Hexadien-1-ol111-28-4 D-Fenchone 4695-62-9 3-Phenylpropyl formate 104-64-3 Cinnamylformate 104-65-4 D-galacturonate 685-73-4 D-glucuronate 1700908 5′ IMP131-99-7 1-Methoxy-4-methylbenzene 104-93-8 2-Methylbutanoic acid116-53-0 2,4,6-Tribromophenol 118-79-6 3-Ethyl pyridine 536-78-7 Zincacetate 557-34-6 Methyl pentanoate 624-24-8 Methylthioethane 624-89-53-Penten-2-one 625-33-2 Glycocholic acid 475-31-0 m-Methoxybenzoic acid586-38-9 alpha-Hydroxypropionic acid 598-82-3 Methyl 2-furoate 611-13-22-Furancarboxylic acid, propyl 615-10-1 ester Benzylacetoacetic acid,ethyl 620-79-1 ester 2,5-Dimethyl pyrrole 625-84-34-methyl-1,1′-biphenyl 644-08-6 p-Isopropylacetophenone 645-13-64-methyl-thiazole 693-95-8 gamma-Decalactone 706-14-9 2-acetylpyrrole1072-83-9 2-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-4Methyl 4-phenylbutyrate 2046-17-5 2,3,6-trimethyl-phenol 2416-94-62-Methoxypyrazine 3149-28-8 2-Ethylfuran 3208-16-0 2,3-dimethyl-pyrazine5910-89-4 Thiophenethiol 7774-74-5 o-Tolyl isobutyrate 36438-54-7cis-3-Hexenyl pyruvate 68133-76-6 cis-3-Hexenyl cis-3-hexenoate61444-38-0 trans-2-Hexenyl isovalerate 68698-59-9 trans-2-Hexenylformate 53398-78-0 trans-2-Hexenyl valerate 56922-74-8 1-Octen-3-ylbutyrate 16491-54-6 Methyl 4-(methylthio)butyrate 53053-51-32,4-Octadien-1-ol 18409-20-6 2,4-Nonadien-1-ol 62488-56-62,4-Decadien-1-ol 18409-21-7 (e,z)-2,6-Nonadienyl acetate 68555-65-73-Hexenal 4440-65-7 Tetrahydro-2-furanmethanol 637-64-9 acetate Methylbenzaldehyde 1334-78-7 Dodecylsulfonic acid 1510-16-3 Methylethyldisulfide 4253-89-8 Farnesol 4602-84-0 Thiobenzoic acid, S-methyl5925-68-8 ester Hexyl benzoate 6789-88-4 2,5-Diethyltetrahydrofuran41239-48-9 Zinc hydrosulfite 7779-86-4 (2R,3S)-Tartaric Acid 147-73-9Ethylsulfuric acid 540-82-9 1,2,2-Trimethyl-1,3- 5394-83-2cyclopentanedicarboxylic acid 2-Methyl-3-buten-2-ol 115-18-4trans-2-Hexenal 6728-26-3 4-Hexen-3-one 2497-21-4 1-Hexen-3-ol 4798-44-12-Methyl-1-butanethiol 1878-18-8 4-Methylcyclohexanone 589-92-43-Heptanol 589-82-2 o-methylanisole 578-58-5 trans-2-octenal 2363-89-52,3,4-Trimethyl-3-pentanol 3054-92-0 Acetylacetaldehyde dimethyl5436-21-5 acetal p-methylacetophenone 122-00-9 o-aminoacetophenone551-93-9 4-Propylphenol 645-56-7 2,4-Dimethylanisole 6738-23-4 Benzylmethyl sulfide 766-92-7 Methyl phenylacetate 101-41-74-Ethoxybenzaldehyde 10031-82-0 p-tolyl acetate 140-39-62,6-Dimethoxyphenol 91-10-1 Isoborneol 124-76-5 Methyl 2-methoxybenzoate606-45-1 Phenylacetaldehyde dimethyl 101-48-4 acetal 3-Phenylpropylacetate 122-72-5 Ethyl 3-phenylpropionate 2021-28-5 Benzyl butyrate103-37-7 Anisyl acetate 104-21-2 Isobutyl phenylacetate 102-13-6p-vinylphenol 2628-17-3 o-tolyl acetate 533-18-6 2,5-Dihydroxybenzoicacid 490-79-9 o-methoxyphenyl acetate 613-70-7 Lactobionic acid 96-82-2Magnesium hydrogen phosphate 7782-75-4 trihydrate Iberverin 505-79-3alpha-methylcinnamaldehyde 101-39-3 benzyl phenylacetate 102-16-91,3-dimercaptopropane 109-80-8 p-cymen-8-ol 1197-01-9 phenethylanthranilate 133-18-6 trihydroxybutyrophenone 1421-63-2o-methoxycinnamaldehyde 1504-74-1 3-propylidene phthalide 17369-59-4trans,trans-2,4-decadienal 25152-84-5 piperonyl acetate 326-61-42,3-hexanedione 3848-24-6 isopropyl phenylacetate 4861-85-2 ethyl3-hydroxybutyrate 5405-41-4 furfural acetone 623-15-4beta-(2-furyl)acrolein 623-30-3 linalyl anthranilate 7149-26-0 citraldiethyl acetal 7492-66-2 allyl anthranilate 7493-63-2 acetyl tributylcitrate 77-90-7 butyl anthranilate 7756-96-9 cyclohexyl anthranilate7779-16-0 isoamyl cinnamate 7779-65-9 isobutyl anthranilate 7779-77-3carvyl acetate 97-42-7 carveol 99-48-9 3-(Methylthio)propionaldehyde3268-49-3 Alpha-damascone 43052-87-5 Dimethyldicarbonate 4525-33-1Procaine 59-46-1 5-hydroxy-6-methyl-3,4- 65-23-6 pyridinedimethanol2-methoxy-Naphthalene 93-04-9 Methyl nicotinate 93-60-7 Ethylbenzoylacetate 94-02-0 Phenethyl benzoate 94-47-3 2-methyl-pentanoicacid 97-61-0 Cyclohexanecarboxylic acid 98-89-5 Methylb-phenylpropionate 103-25-3 Benzyl 3-methyl butanoate 103-38-8Naphthalene-2-sulfonic acid 120-18-3 Methyl 4-methoxybenzoate 121-98-23-Phenylprop-2-enyl cinnamate 122-69-0 7-methyl-3-methylene-1,6-123-35-3 Octadiene Levulinic acid 123-76-2 2-Mercaptobenzoic acid147-93-3 m-Dimethoxybenzene 151-10-0 3-butyl-1(3H)-isobenzofuranone6066-49-5 5-Methylquinoxaline 13708-12-8 2-Ethyl Pyrazine 13925-00-3trimethyl-pyrazine 14667-55-1 2-ethyl-3-methyl-pyrazine 15707-23-02,3-diethyl-pyrazine 15707-24-1 2,3-diethyl-5-methyl-pyrazine 18138-04-02-Methylthiopyrazine 21948-70-9 5-Methyl-3H-furan-2-one 591-12-8cis-3-Hexen-1-ol 928-96-1 3,7-Dimethyl-1,3,6-octatriene 13877-91-3calcium cyclamate 139-06-0 aconitic acid 499-12-7 2-Dehydrolinalool29171-20-8 2-Mercaptopropionic acid 79-42-5 3-Methyl-2-butenal 107-86-8Allylacetic acid 591-80-0 Allyl cyclohexylacetate 4728-82-9 Allylcyclohexylpropionate 2705-87-5 Allyl phenoxyacetate 7493-74-5 Allylphenylacetate 1797-74-6 Allyl alpha-ionone 79-78-7 Butyl butyrolactate7492-70-8 Cinnamyl isobutyrate 103-59-3 Cinnamyl propionate 103-56-0Dibenzyl disulfide 150-60-7 Isobornyl acetate 125-12-2 Methyl heptynecarbonate 111-12-6 Triethyl citrate 77-93-0 gamma-Undecalactone 104-67-6alpha-Amylcinnamyl alcohol 101-85-9 1,3,4,6,7,8-Hexahydro- 1222-05-54,6,6,7,8,8-hexamethyl cyclopenta[g][2]benzopyran 2-Ethylbutyl acetate10031-87-5 Triphosphoric acid, 13845-36-8 pentapotassium saltL-(+)-Lactic acid 79-33-4 Mannitol 87-78-5 2-Methoxy-4-methylphenol93-51-6 1,2,3-Propanetricarboxylic 144-33-2 acid, 2-hydroxy-, disodiumsalt Ethanesulfonic acid, 2- 1562-00-1 hydroxy-, monosodium salt2-Methoxy-4-propylphenol 2785-87-7 3,7-Dimethyl-3-octanol 78-69-32-Pentyl-furan 3777-69-3 Butanoic acid, 3-oxo-, butyl 591-60-6 ester4-(4-Hydroxy-4-methyl pentyl)- 31906-04-4 3-cyclohexene-1-carboxaldehydeMethyl 3-oxo-2- 24851-98-7 pentylcyclopentaneacetate Naphthalene, 2-(2-2173-57-1 methylpropoxy)- Perillol 536-59-4 2-Acetyl-1-methylpyrrole932-16-1 4-Allyl-2,6-dimethoxyphenol 6627-88-9 Butyl levulinate2052-15-5 D-(+)-Camphoric acid 124-83-4 D(+)-10-Camphorsulfonic acid3144-16-9 L-(−)-Carvone 6485-40-1 (−)-Carvyl propionate 97-45-0(−)-Caryophyllene oxide 1139-30-6 Cyclohexylacetic acid 5292-21-73-Cyclopentylpropionic acid 140-77-2 (−)-Dihydrocarvyl acetate20777-49-5 3,3-Dimethylacrylic acid 541-47-9 2,4-Dimethylbenzaldehyde15764-16-6 1,4-Dithiane-2,5-diol 40018-26-6 Ethanesulfonic acid 594-45-6Ethyl butyrylacetate 3249-68-1 Ethyl (methylthio)acetate 4455-13-4 Ethylpyruvate 617-35-6 Ethyl sorbate 2396-84-1 5-Formyl-2-furansulfonic acid,31795-44-5 sodium salt Furfuryl mercaptan 98-02-2 1,6-Hexanedithiol1191-43-1 trans-2-Hexenoic acid 13419-69-7 trans-2-Hexen-1-ol 928-95-04-(4-Hydroxyphenyl)-2-butanone 5471-51-2 Isopulegol 89-79-2 Isopulegylacetate 89-49-6 2-Ketobutyric acid 600-18-0 (−)-Limonene 5989-54-84-Methoxyphenylacetone 122-84-9 Methyl cyclohexanecarboxylate 4630-82-43-Methylcyclohexanone 591-24-2 3-Methyl-2-cyclohexen-1-one 1193-18-63-Methyl-1,2-cyclopentanedione 765-70-8 3-Methyl-2-cyclopenten-1-one2758-18-1 N-Methyl-D-glucamine 6284-40-8 Methyl 3- 13532-18-8(methylthio)propionate 4-Methyl-5-thiazoleethanol 137-00-8 5-Methyl-2-13679-70-4 thiophenecarboxaldehyde DL-3-Methylvaleric acid 105-43-1(−)-Myrtenal 564-94-3 Nopol 128-50-7 gamma-Octanoic lactone 104-50-73-Octanol 589-98-0 E-2-Octenoic acid 1871-67-6 Pamoic acid 130-85-84-Phenyl-2-butyl acetate 10415-88-0 1-Phenyl-1,2-propanedione 579-07-72-Phenylpropyl butyrate 80866-83-7 2-Phenylpropyl isobutyrate 65813-53-8cis-2-Hexen-1-ol 928-94-9 Bis(methylthio)methane 1618-26-4 Magnesiumcarbonate hydroxide, 39409-82-0 Light N-Acetyl-L-methionine 65-82-74-Methyl-5-vinylthiazole 1759-28-0 2-Methyl-1-phenyl-2-propanol 100-86-73-Phenylpropionaldehyde 104-53-0 N-Benzyl-2-phenylethylamine 3647-71-01-Phenylethyl propionate 120-45-6 3-Phenylpropyl isobutyrate 103-58-2Allyl hexanoate 123-68-2 alpha, 4-Dimethylbenzylalcohol 536-50-5(−)-Menthyl lactate 59259-38-0 2,6-Dimethylthiophenol 118-72-92,4,5-Trimethylthiazole 13623-11-5 Ethyl 3-(methylthio)propionate13327-56-5 Phenylethyl isovalerate 140-26-1 2-Propylpyrazine 18138-03-92-Methyltetrahydrofuran-3-one 3188-00-9 Ethyl 2- 23747-43-5(methyldithio)propionate 3,4-Dimethyl-1,2- 13494-06-9 cyclopentanedioneDifurfurylsulfide 13678-67-6 Difurfuryldisulfide 4437-20-13-(Methylthio)propanol 505-10-2 Methyl phenyl disulfide 14173-25-22-(Methyldithio)- 67952-60-7 isobutyraldehyde Methyl 2-thiofuroate13679-61-3 2-Isobutylthiazole 18640-74-9 4-Methyl-5-thiazolylethyl656-53-1 acetate 2-Acetylthiazole 24295-03-2 2-Ethyl-3,5(6)- 27043-05-6dimethylpyrazine 5-Methyl-6,7-dihydro-5H- 23747-48-0cyclopenta(b)pyrazine Cinnamyl acetate 103-54-82,5-Dihydroxy-2,5-dimethyl- 55704-78-4 1,4-dithiane5,6,7,8-Tetrahydroquinoxaline 34413-35-9 2-Methyl-3-furanethiol28588-74-1 Styrallyl acetate 93-92-5 2-Methylhexanoic acid 4536-23-62-Methylheptanoic acid 1188-02-9 2,2,6-Trimethylcyclohexanone 2408-37-9L-Tyrosine ethyl ester 4089-07-0 hydrochloride Ethyl 4-methoxybenzoate94-30-4 4-Ethylbenzaldehyde 4748-78-1 N-Ethyl-p-menthane-3- 39711-79-0carboxamide 1-(2-Furyl)-1,3-butanedione 25790-35-6 Menthofuran 494-90-6Methylsulfuric acid sodium 512-42-5 salt Sucrose diacetate 126-13-6hexaisobutyrate N,2,3-Trimethyl-2- 51115-67-4 isopropylbutamideTripropionin 139-45-7 (+/−)-Citronellic acid 502-47-65-Acetyl-2,4-dimethylthiazole 38205-60-6 Neryl acetate 141-12-8 Benzylpropionate 122-63-4 1R-(−)-Camphorsulfonic acid 35963-20-33,4-Hexanedione 4437-51-8 cis-3-Hexenoic acid 4219-24-3 cis-4-Heptenal6728-31-0 (E,Z)-2,6-nonadienal 557-48-2 trans-2,trans-6-Nonadienal17587-33-6 4-Methyl-2-pentenal 5362-56-1 cis-6-Nonenal 2277-19-2 Methylpropyl disulfide 2179-60-4 8-p-Menthen-1-ol 138-87-4 p-Menthan-2-one499-70-7 Bisabolene 495-62-5 Ethyl cyclohexanecarboxylate 3289-28-9Phenylpyruvate 156-06-9 Hydroxypyruvate 1113-60-64-Methyl-2-oxopentanoate 816-66-0 (+)-Neomenthol 2216-52-6 trans-Citral141-27-5 Piperitenone 491-09-8 Sabinene hydrate 546-79-2 Perillylaldehyde 2111-75-3 2-Hydroxyethanesulfonate 107-36-8 Acetyl isovaleryl13706-86-0 Acetyl valeryl 96-04-8 Butylidene phthalide 551-08-6Carvacryl ethyl ether 4732-13-2 Ethyl vanillin propylene 68527-76-4glycol acetal Hexyl hexanoate 6378-65-0 2-Methyl-5-(methylthio)-furan13678-59-6 2-Methyl-4-pentenoic acid 1575-74-2 2-Methyl-4-propyl-1,3-67715-80-4 oxathiane 3-Methylthio-1-hexanol 51755-66-9 cis-6-Nonenol35854-86-5 Rose oxide 16409-43-1 L-Linalool 126-91-0 5,6-Dimethyl-8-4674-50-4 isopropenylbicyclo[4.4.0]dec- 1-en-3-one2-Ethyl-3,5-dimethylpyrazine 13925-07-0 2-Isopropylpyrazine 29460-90-02-Isobutyl-3-methyl-pyrazine 13925-06-9 2-Methoxy-3-sec-butyl-pyrazine24168-70-5 2-Methylthio-3(6)-methyl- 67952-65-2 pyrazine Benzylcarbinylpropionate 122-70-3 Bornyl acetate 76-49-3 furaneol 3658-77-3Methoxycinnamaldehyde 1963-36-6 Methylphenol, hydrogen sulfate68127-34-4 Lactitol monohydrate 81025-04-9 2H-Pyrrole, 3,4-dihydro-5724-81-2 2-Butenal, 2-methyl-, (E)- 497-03-0 2-Pentenal 764-39-6Ethanethioic acid, S-methyl 1534-08-3 ester 2-Hexenal 505-57-72-Methyl-2-pentenal 623-36-9 Cyclopentanethiol 1679-07-8 Butane,2-ethoxy- 2679-87-0 S-Ethyl thioacetate 625-60-5 ethyl methyl carbonate623-53-0 3(2H)-Furanone, 2,5-dimethyl- 14400-67-0 Allyl propionate2408-20-0 methyl 2-methylbutanoate 868-57-5 2-Butanone, 1-(methylthio)-13678-58-5 Ethanethioic acid, S-propyl 2307-10-0 ester 1,2-Butanedithiol16128-68-0 6-Methyl-3,5-heptadiene-2-one 1604-28-0 2-Octen-4-one4643-27-0 2,5-dimethyl-3-furanthiol 55764-23-3 2-Heptenoic acid18999-28-5 Butanoic acid, 2-propenyl 2051-78-7 ester6-Methyl-5-hepten-2-ol 1569-60-4 trans-2-Octen-4-ol 20125-81-9cis-3-Octen-1-ol 20125-84-2 1-Butanol, 2-methyl-, acetate 624-41-94-methyl-alpha-methylstyrene 1195-32-0 trans-3-phenyl-2-propen-1-ol4407-36-7 Benzeneacetaldehyde, alpha- 93-53-8 methyl- Benzene,(2-methoxyethyl)- 3558-60-9 Cyclohexene, 1-methyl-4-(1- 7705-14-8methylethenyl)-, (+−)- Phenol, 2-(methylthio)- 1073-29-6 2-Hexen-1-ylacetate 2497-18-9 3-Hexen-1-ol, acetate, (Z)- 3681-71-85-Hydroxy-4-octanone 496-77-5 butyl 2-methylpropanoate 97-87-0Benzofuran-2-carboxaldehyde 4265-16-1 DL-Lysine 70-54-2 1-Hexanethiol,2-ethyl- 7341-17-5 2′,4′-Dimethylacetophenone 89-74-7 2-Pentylpyridine2294-76-0 1-Methoxy-4-propyl benzene 104-45-01-Hydroxy-2-methoxy-4-ethyl 2785-89-9 benzene Nonalactone 6008-27-1Cyclohexyl propionate 6222-35-1 Allyl 2-ethylbutyrate 7493-69-8 Butanoicacid, 3-oxo-, 2- 7779-75-1 methylpropyl ester n-Butyl pentanoate591-68-4 3,7-Dimethyl-1-octanol 106-21-8 3-Buten-2-one, 3-methyl-4-1901-26-4 phenyl- 2-Propenoic acid, 3-phenyl-, 1754-62-7 methyl ester,(E)- Benzene, 4-ethenyl-1,2- 6380-23-0 dimethoxy- Benzenepropanol,alpha,alpha- 103-05-9 dimethyl- Benzene, (butoxymethyl)- 588-67-0Dimethyl anthranilate 85-91-6 2-Hexanoylfuran 14360-50-0 Cyclohexylbutyrate 1551-44-6 Naphthalene, 2-ethoxy- 93-18-5 Acetoacetic acidisoamyl ester 2308-18-1 Propanoic acid, 2-methyl-, 4- 103-93-5methylphenyl ester 4-(4-Methoxyphenyl)-2-butanone 104-20-1 Isobutylbenzoate 120-50-3 Benzene, 1,2-dimethoxy-4-(1- 93-16-3 propenyl)- beta-10415-87-9 Phenylethylmethylethylcarbinol 1,1-Dimethoxy-2-phenylpropane90-87-9 Geranyl formate 105-86-2 Bornyl formate 7492-41-3 6-Octen-1-ol,3,7-dimethyl-, 105-85-1 formate Benzeneacetic acid, butyl 122-43-0 ester3,5,9-Undecatrien-2-one, 6,10- 141-10-6 dimethyl- Anisyl propionate7549-33-9 Butanoic acid, 3-phenyl-2- 103-61-7 propenyl ester 2-Propenoicacid, 3-phenyl-, 122-67-8 2-methylpropyl ester Eugenyl acetate 93-28-73-Methylbutyl phenylacetate 102-19-2 Benzoic acid, 2-(methylamino)-,65505-24-0 2-methylpropyl ester Phenoxy ethyl isobutyrate 103-60-6Anisyl butyrate 6963-56-0 2,6-Octadien-1-ol, 3,7- 105-91-9 dimethyl-,propanoate, (Z)- Isobornyl propionate 2756-56-1 1,3,5-Trithiane,2,2,4,4,6,6- 828-26-2 hexamethyl- Geranyl N-butyrate 106-29-6 Geranylisobutyrate 2345-26-8 Thiophene, 2,2′-dithiobis- 6911-51-9 2-Propenoicacid, 3-phenyl-, 7779-17-1 cyclohexyl ester Benzeneacetic acid,3-phenyl- 7492-65-1 2-propenyl ester Anisyl phenylacetate 102-17-02-Propenoic acid, 3-phenyl-, 122-68-9 3-phenylpropyl ester Geranylphenylacetate 102-22-7 hexyl 2-methylbutyrate 10032-15-2 4-heptanolide105-21-5 Neral 106-26-3 (E)-2-octenol 18409-17-1 Ethyl3-hydroxyhexanoate 2305-25-1 isopropyl hexanoate 2311-46-8 hexylbutanoate 2639-63-6 bis(2-methyl-3-furyl)disulfide 28588-75-23-hydroxy-4,5-dimethyl-2(5H)- 28664-35-9 furanone 2-acetyl-2-thiazoline29926-41-8 (E,E)-2,4-octadienal 30361-28-5 geranyl acetone 3796-70-11-octen-3-one 4312-99-6 3-mercapto-2-pentanone 67633-97-0 (Z)-3-hexenal6789-80-6 4-hexanolide 695-06-7 5-octanolide 698-76-0 delta-decalactone705-86-2 4-vinylguaiacol 7786-61-0 Amyl salicylate 2050-08-0 Cyclohexylformate 4351-54-6 Dimethylbenzylcarbinyl acetate 151-05-3 Geranylpropionate 105-90-8 Terpinyl acetate 80-26-2 isopropyl 3-methylbutanoate32665-23-9 isopropyl 2-methylbutanoate 66576-71-4 3-Hexenyl3-methylbutanoate 10032-11-8 Isoamyl 2-methylbutyrate 27625-35-0 3-Octylacetate 4864-61-3 Benzyl isobutyrate 103-28-6 Cis-3-hexenyl butyrate16491-36-4 Cis-3-hexenyl lactate 61931-81-5 Citronellyl butyrate141-16-2 Citronellyl propionate 141-14-0 Isoamyl hexanoate 2198-61-01,3,5-Undecatriene 16356-11-9 1-Benzyloxy-2-methoxy-4- 120-11-6 propenylbenzene 1-Octen-3-yl acetate 198242 2-Acetyl-3-ethyl pyrazine 32974-92-82-Isopropyl-4-methyl thiazole 15679-13-7 2-Methyl-2-pentenoic acid3142-72-1 2-sec-butyl thiazole 18277-27-5 4,5-Dimethyl thiazole3581-91-7 4-(2,6,6-Trimethyl-2- 31499-72-6 cyclohexen-1-yl)butan-2-one4-(2,6,6-Trimethyl cyclohexa- 23696-85-7 1,3-dienyl)but-2-en-4-oneAcetaldehyde phenethyl propyl 7493-57-4 acetal Acetaldehyde ethyl cis-3-28069-74-1 hexenyl acetal Acetone propylene glycol 1193-11-9 acetalAcetyl isoeugenol 93-29-8 2-Acetyl-5-methyl furan 1193-79-9 Allylcyclohexylbutyrate 7493-65-4 Alpha,alpha-dimethylphenethyl 10094-34-5butyrate Alpha,alpha-dimethyl phenethyl 10058-43-2 formateAlpha,beta-santalol 11031-45-1 Alpha-amyl cinnamaldehyde 91-87-2dimethyl acetal Alpha-fenchyl acetate 13851-11-1 Alpha-furfurylpentanoate 36701-01-6 Alpha-ionol 25312-34-9 6-Methyl-alpha-ionone79-69-6 Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehydeAlpha-n-amyl-beta-phenylacryl 7493-78-9 acetate Alpha-piperitone6091-50-5 Alpha-n-amyl-beta-phenyl acryl 7493-80-3 isovalerate6-Amyl-alpha-pyrone 27593-23-3 Anisyl formate 122-91-8 Benzylcarbinyl2-methyl 24817-51-4 butyrate Benzylcarbinyl 3-phenyl 103-53-7 propenoateBenzylcarbinyl alpha-toluate 102-20-5 Benzylcarbinyl butyrate 103-52-6Benzylcarbinyl caproate 6290-37-5 Benzylcarbinyl formate 104-62-1Benzylcarbinyl isobutyrate 103-48-0 Benzylcarbinyl salicylate 87-22-9Benzylcarbinyl tiglate 55719-85-2 Benzyl dipropyl ketone 7492-37-7Benzyl tiglate 37526-88-8 Beta-homocyclocitral 472-66-2 Beta-ionol22029-76-1 3-Phenylpropyl propanoate 122-74-7 Bois de rose oxide7392-19-0 Butyl 2-methyl butyrate 15706-73-7 Butyl cinnamate 538-65-8ortho-sec-Butyl cyclohexanone 14765-30-1 isobutyl cis-2-methyl-2-7779-81-9 butenoate 5-n-Butyl-delta-valerolactone 3301-94-8 Campholenicaldehyde 4501-58-0 Cedran-8-yl acetate 77-54-3 Cinnamyl isovalerate140-27-2 Cis-3-hexenyl benzoate 25152-85-6 Cis-3-hexenyl caproate31501-11-8 Cis-3-hexenyl formate 33467-73-1 Cis-3-hexenyl isobutyrate41519-23-7 Cis-3-hexenyl phenylacetate 42436-07-7 Cis-3-hexenylpropionate 33467-74-2 Cis-3-hexenyl tiglate 67883-79-8 Cis-3-hexenylvalerate 35852-46-1 cis-4-Hepten-1-ol 6191-71-5 Cis-5-octen-1-ol64275-73-6 Citral dimethyl acetal 7549-37-3 Citronellyl isobutyrate97-89-2 Citronellyl isovalerate 68922-10-1 Citronellyl valerate7540-53-6 Citroxide 7416-35-5 Cocal 21834-92-4 p-Cresyl alpha-toluate101-94-0 p-Cresyl isovalerate 55066-56-3 Dehydro-beta-cyclocitral116-26-7 8,8-Diethoxy-2,6-dimethyl-2- 7779-94-4 octanol5,7-Dihydro-2-methyl 36267-71-7 thieno(3,4-d)pyrimidine2,5-Dihydro-4,5-dimethyl-2-(2- 65894-83-9 methyl propyl)thiazoleDihydrojasmone 1128-08-1 Dihydroxyacetophenone 28631-86-91,1-Dimethoxy-3,7-dimethyl-7- 141-92-4 octanol3,7-Dimethyl-1,6-octadien-3-yl 126-64-7 benzoate3,7-Dimethyl-1,6-octadien-3-yl 78-36-4 butyrate3,7-Dimethyl-1,6-octadien-3-yl 78-35-3 isobutyrate3,7-Dimethyl-1,6-octadien-3-yl 144-39-8 propanoatecis-3,7-Dimethyl-2,6-octadien- 2345-24-6 1-yl 2-methyl propanoate2,4-Dimethyl-3-cyclohexene-1- 68039-49-6 carboxaldehyde2,6-Dimethyl-5-hepten-1-al 106-72-9 trans,cis-2,6-Dodecadien-1-al21662-13-5 Eglantal 26643-91-4 Ethyl E-2-hexenoate 27829-72-7 Ethyltiglate 5837-78-5 Ethyl trans-4-decenoate 76649-16-65-Ethyl-4-hydroxy-2-methyl- 27538-09-6 3[2H]furanone 2-Ethyl-4-methylthiazole 15679-12-6 2,6,10-Trimethyl-2,6,10- 762-29-8pentadecatrien-14-one Guaiacyl phenyl acetate 4112-89-4 3-Hepten-2-one1119-44-4 trans-2-Hexen-1-ol 2305-21-7 Trans-2-hexenyl butyrate53398-83-7 Hexyl phenylacetate 5421-17-0 Hexyl propionate 2445-76-3Hydroxycitronellol 107-74-4 Isobutyl 2-butenoate 589-66-2 Isobutylsalicylate 87-19-4 Isodihydro lavandulal 35158-25-9 Isoeugenyl phenylacetate 120-24-1 Isopropyl alpha- 1733-25-1 methylcrotonatep-Menth-1-en-8-yl propionate 80-27-3 Menthalactone 13341-72-53-Methoxy-p-cymene 1076-56-8 Methyl 4-methyl pentanoate 2412-80-8alpha-Methyl benzyl formate 7775-38-4 2-Methylbutyl 2- 2445-78-5methylbutanoate Methyl e-2-octenoate 2396-85-2 p-Methylhydratropaldehyde 99-72-9 3-(5-Methyl-2-furyl)butanal 31704-80-0 Neroloxide 1786-08-9 trans,cis-2,6-Nonadien-1-ol 7786-44-9 trans-2-Octen-1-ylacetate 3913-80-2 3-Octen-2-one 1669-44-9 2-Phenyl-2-butenal 4411-89-62-Propionylthiazole 43039-98-1 1-Hydroxy-2-butanone 5077-67-82-Butanone, 3-hydroxy-, (+−)- 52217-02-4 Thiazole, 2,5-dimethyl-4175-66-0 Butanethioic acid, S-methyl 2432-51-1 ester 2,4-Hexadienoicacid, methyl 689-89-4 ester, (E,E)- Benzeneacetaldehyde, 4-methyl-104-09-6 Bicyclo[4.1.0]hept-3-ene, 498-15-7 3,7,7-trimethyl-, (1S)-Ethyl 3-hexenoate 2396-83-0 1H-Pyrrole, 1-(2- 1438-94-4 furanylmethyl)-6-Octenal, 3,7-dimethyl-, (R)- 2385-77-5 Ethanethioic acid, S-(2-13678-68-7 furanylmethyl) ester 6-Octen-1-ol, 3,7-dimethyl-, 1117-61-9(R)- 6-Octen-1-ol, 3,7-dimethyl-, 7540-51-4 (S)- DL-Tetrohydrofurfuryl637-65-0 propionate Benzenepentanol 10521-91-2 Cyclohexaneethanol,acetate 21722-83-8 Benzyl isobutyl ketone 5349-62-2 Butanoic acid,3-oxo-, 5396-89-4 phenylmethyl ester 1,2-Ethanediamine, N,N′- 140-28-3bis(phenylmethyl)- 2-Ethyl-3-hydroxy-4-pyrone 1110651 Dicyclohexyldisulfide 2550-40-5 Tetrahydrofurfuryl butyrate 2217-33-6 Thujone546-80-5 Benzyl alcohol, alpha-methyl-, 3460-44-4 butyrate Citronellyltiglate 24717-85-9 Lactitol 585-86-4 Nonivamide 2444-46-42-Acetoxy-3-butanone 4906-24-5 3-Acetyl-2,5-dimethylthiophene 2303783-Acetyl-2-5dimethylfuran 10599-70-9 4-Acetyl-6-t-butyl-1,1- 13171-00-1dimethylindan Allyl 2-furoate 4208-49-5 Allyl sorbate 7493-75-6 Allylthiopropionate 41820-22-8 Allyl tiglate 7493-71-2 Amylcyclohexyl acetate67874-72-0 Benzaldehyde glyceryl acetal 1319-88-6 Benzaldehyde propyleneglycol 2568-25-4 acetal Bornyl isovalerate 76-50-6 1,3-Butanedithiol24330-52-7 2,3-Butanedithiol 4532-64-3 Butyl cinnamic aldehyde 7492-44-6Cinnamyl benzoate 5320-75-2 Citral ethylene glycol acetal 66408-78-4Citronellyloxyacetaldehyde 7492-67-3 Citronellyl phenylacetate 139-70-8Cyclohexyl isovalerate 7774-44-9 Decalactone 5579-78-22,5-Dimethyl-4-methoxy-3(2H)- 4077-47-8 furanone6,10-Dimethyl-9-undecen-2-one 4433-36-7 2-Ethoxythiazole 15679-19-3Ethyl 2-mercaptopropionate 19788-49-9 Ethyl 2-methyl-4-pentenoate53399-81-8 Ethyl 3-(2-furyl)propanoate 94278-27-0 Ethylcyclohexanepropionate 10094-36-7 Ethyl (p-tolyloxy)acetate 67028-40-43-Ethyl-2-hydroxy-2- 21835-01-8 cyclopenten-1-one Ethylene brassylate105-95-3 2-Ethylfenchol 18368-91-7 Furfuryl 3-methylbutanoate 13678-60-9Furfuryl butyrate 623-21-2 Furfuryl isopropyl sulfide 1883-78-9 Furfurylmethyl sulfide 1438-91-1 Furfuryl propionate 623-19-8 Furfurylthiopropionate 59020-85-8 Geranyl acetoacetate 10032-00-5 Geranylbenzoate 94-48-4 Geranyl isovalerate 109-20-6 delta-Hexalactone 823-22-3trans-3-Hexenal 69112-21-6 cis-3-Hexenyl anthranilate 65405-76-7trans-2-Hexenyl propionate 53398-80-4 5-(cis-3-Hexenyl) dihydro-5-70851-61-5 methyl-2(3H)furanone Hexyl 2-formate 39251-86-0 Hexylcrotonate 19089-92-0 Hexyl formate 629-33-4 Isoamyl3-(2-furyl)propionate 7779-67-1 Isoamyl pyruvate 7779-72-8 Isobutylfurylpropionate 105-01-1 Isohexenyl cyclohexenyl 37677-14-8carboxaldehyde p-Isopropyl phenylacetaldehyde 4395-92-0 Linalylcinnamate 78-37-5 Linalyl formate 115-99-1 Linalyl isovalerate 1118-27-0Linalyl phenylacetate 7143-69-3 Maltol isobutyrate 65416-14-0 Methyl2-methylpentanoate 2177-77-7 Methyl 3-hydroxyhexanoate 21188-58-9 Methyl3-nonenoate 13481-87-3 Methyl furfuryl disulfide 57500-00-2 Methylp-tert- 3549-23-3 butylphenylacetate 3-Methyl-1,2-cyclohexanedione3008-43-3 alpha-Methylanisalacetone 104-27-8 2-Methylbutyl isovalerate2445-77-4 4-Methylnonanoic acid 45019-28-1 4-Methyloctanoic acid54947-74-9 2-Methyltetrahydrothiophen-3- 13679-85-1 one3-(Methylthio)butanal 16630-52-7 4-(Methylthio)butanol 20582-85-84-Methylthio-2-butanone 34047-39-7 4-Methylthio-4-methyl-2- 23550-40-5pentanone Neryl butyrate 999-40-6 Neryl formate 2142-94-1 Nerylisovalerate 3915-83-1 Octahydrocoumarin 4430-31-3 Phenethyl 2-furoate7149-32-8 1-Phenyl-2-pentanol 705-73-7 Phenylacetaldehyde 68345-22-2diisobutylacetal Phenylacetaldehyde glyceryl 29895-73-6 acetal2-(3-Phenylpropyl)pyridine 2110-18-1 Propyl phenylacetate 4606-15-9Pyrazineethanethiol 35250-53-4 Ethyl 2-methyl pentanoate 39255-32-8Methyl 2,4-decadienoate 4493-42-9 alpha-Isomethyl ionone 127-51-55-Methyl hexanoic acid 628-46-6 Ethyl 3-methyl pentanoate 5870-68-8Ethyl 2-methyl-3,4- 60523-21-9 pentadienoate 3-Nonen-2-one 14309-57-05-Methyl-3-hexen-2-one 5166-53-0 Maltol propionate 68555-63-52-Methyl-3-(2-furyl) acrolein 874-66-8 Ethyl 3(2-furyl)propanoate10031-90-0 2-Phenyl-3-(2-furyl)-propenal 57568-60-24-Methyl-2-pentyl-1,3- 1599-49-1 dioxolane 2-Ethyl-4,5-dimethyl oxazole53833-30-0 Isobornyl isovalerate 7779-73-9 Theophylline-7-acetic acid652-37-9 Ethyl trans-2-octenoate 7367-82-0 DL-Arginine 7200-25-1 AllylCrotonate 20474-93-5 2-Methoxystyrene 612-15-7 Magnesium Fumarate7704-71-4 2-Propionylpyrrole 1073-26-3 2-methyl-1,3-dithiolane 5616-51-32-ethyl-5-methyl pyrazine 13360-64-0 2-methyl-3-(dimercaptomethyl)-65505-17-1 furan Magnesium gluconate 3632-91-5 Manganese gluconate6485-39-8 Erythritol 149-32-6 D-Arabinose 28697-53-2 D-Galactose 59-23-4D-(+)-Mannose 3458-28-4 Sorbitol 50-70-4 Aspartame 22839-47-0 CyclamicAcid 100-88-9 Dulcin 150-69-6 Glucose-1-phosphate 29732-59-0 DipotassiumSalt L-(+)-Arabinose 87-72-9 Fructose-6-Phosphate 643-13-0 D-MaltoseMonohydrate 6363-53-7 Ribose 24259-59-4 Fructose 1,6-Diphosphate26177-85-5 Disodium Salt Saccharin sodium, dihydrate 6155-57-31,2-Benzisothiazol-3(2H)-one 6485-34-3 1,1-dioxide, calcium salt1,2-Benzisothiazolin-3-one 10332-51-1 1,1-dioxide, potassium saltzeranol 26538-44-3 beta-D-fructopyranose 7660-25-5 D-fructose1,6-bisphosphate 488-69-7 Ribose 5-phosphate 4300-28-1 Arabinose147-81-9 Saccharin, sodium salt hydrate 82385-42-0 Maltitol 585-88-6D-Fructose 1-phosphate 15978-08-2 D-Sorbitol 6-phosphate 108392-12-alpha-D-Xylose 31178-70-8 Inositol 1-phosphate 573-35-3

Name CAS # Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate7558-79-4 Sodium Phosphate Monobasic 7558-80-7 Sodium thiosulfate7772-98-71 Orthoboric acid 10043-35-3 Diethanolamine 111-42-2Benzaldehyde 100-52-7 Sorbic acid 110-44-1 L-(+)-Tartaric Acid 87-69-4D-mannitol 69-65-8 Butyl paraben 94-26-8 Thymol 89-83-8 Methylsalicylate 119-36-8 Citric acid 77-92-9 Creatinine 60-27-5 Vitamin C50-81-7 Benzoic Acid 65-85-0 Methyl 4-hydroxybenzoate 99-76-3 m-Cresol108-39-4 p-Cresol 106-44-5 Aspirin 50-78-2 Phenol 108-95-2 Sucrose57-50-1 Potassium citrate, monohydrate 1534146 Sodium acetate 127-09-3Lactic acid 50-21-5 Propionic acid, sodium salt 65-85 Benzyl alcohol100-51-6 Phenethyl alcohol 60-12-8 Cholesterol 57-88-5 D-Glucose 50-99-7Sorbitol 50-70-4 Aspartame 22839-47-0 Saccharin 81-07-22,6-Di-tert-Butyl-p-Cresol 128-37-0 4-Chloro-3-methylphenol 59-50-7glycerin 56-81-5 Propyl paraben 94-13-3 fumaric acid 110-17-8 dabco280-57-9 p-Phenylenediamine 106-50-3 Anethole 4180-23-8 propyl gallate121-79-9 L-monosodium glutamate 142-47-2 Butylated hydroxyanisole25013-16-5 Cyclohexanol, 5-methyl-2-(1- 89-78-1 methylethyl)-,(1alpha,2beta,5alpha)- alpha-Thioglycerol 96-27-5 Sodium dehydroacetate4418-26-2 Ethyl 4-hydroxybenzoate 120-47-8 Ethyl Vanillin 121-32-4Triacetin 102-76-1 Potassium sorbate 590-00-1 Triethyl citrate 77-93-0(S)-(+)-Arginine 74-79-3 Glycine 56-40-6 (S)-(−)-Histidine 71-00-1(S)-(+)-Lysine 56-87-1 Quinone 106-51-4 Naphthalene, 2-ethoxy- 93-18-5Methanesulfonic Acid 75-75-2 DL-Tartaric Acid 133-37-9 Cyclamic acid100-88-9 (S)-(−)-Phenylalanine 63-91-2 (S)-(−)-Tyrosine 60-18-4 Carvone99-49-0 Ethyl butyrate 105-54-4 6-Methyl-5-hepten-2-one 110-93-0 Ethylacetoacetate 141-97-9 Methyl benzoate 93-58-3 Phenylacetic Acid 103-82-2Adipic acid 124-04-9 Ethyl benzoate 93-89-0 Benzyl benzoate 120-51-4Pyruvic acid 127-17-3 Succinic acid 110-15-6 Indole 120-72-9 Methylanthranilate 134-20-3 Diethyl malonate 105-53-3 Niacin 59-67-6Meso-inositol 87-89-8 4-Aminobenzoic acid 150-13-0 Anisole 100-66-3 Urea57-13-6 Pyrrolidine 123-75-1 Cyclopentanone 120-92-3 Acetic anhydride108-24-7 Benzophenone 119-61-9 D-(−)-Fructose 57-48-7 D-(+)-Xylose58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethylisovalerate 108-64-5 1,1′-Azobisformamide 123-77-3 6-Methylcoumarin92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2 Cymene 99-87-6Dimethyl Succinate 106-65-0 p-Anisaldehyde 123-11-5 Phenyl ether101-84-8 Tetrahydro-2-furanmethanol 97-99-4 Valeric Acid 109-52-43,4-xylenol 95-65-8 1,1-diethoxyethane 105-57-7 ethyl butyraldehyde97-96-1 Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 methylisovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde123-15-9 4-(2,6,6-Trimethyl-2- 127-41-3 cyclohexen-1-yl)-3-buten-2-one4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1-yl)-3-buten-2-one Maleicacid 110-16-7 3-Methylbutanoic acid 503-74-2 L-Glutamic Acid 56-86-0D-limonene 5989-27-5 1-Phenyl-1-propanol 93-54-9 2′-Hydroxyacetophenone118-93-4 2,4-Dihydroxybenzoic Acid 89-86-1 2-Phenyl-1-propanol 1123-85-93-Phenylpropionic Acid 501-52-0 4-Ethoxyphenol 622-62-8 Alpha-Terpineol98-55-5 Benzaldehyde Dimethylacetal 1125-88-8 Benzyl Ether 103-50-4Benzyl Formate 104-57-4 Benzyl Salicylate 118-58-1 Cinnamyl Alcohol104-54-1 D-(+)-Glucono-1,5-lactone 4253-68-3 D-Isoascorbic Acid 89-65-62,3-Naphthalenediol 92-44-4 Diethyl Succinate 123-25-1 Ethyl2-Aminobenzoate 87-25-2 Ethyl Cinnamate 103-36-6 Ethyl Phenylacetate101-97-3 Ethyl Salicylate 118-61-6 gamma-Valerolactone 108-29-2Hydroquinone Dimethyl Ether 150-78-7 Isocaproic Acid 646-07-1 Isoeugenol97-54-1 Isopropyl Benzoate 939-48-0 L-(+)-Isoleucine 73-32-5 L-Malicacid 97-67-6 L-2-Aminopropionic Acid 56-41-7 L-Carnitine 541-15-1L-Glutamine 56-85-9 L-Hydroxyproline 51-35-4 L-Proline 147-85-3 L-Serine56-45-1 L-Threonine 72-19-5 L-Valine 72-18-4 Phenoxyacetic Acid 122-59-8Veratrole 91-16-7 2-Ethylbutyric acid 88-09-5 2-Methylpyrazine 109-08-0o-methoxybenzaldehyde 135-02-4 L-Leucine 61-90-5 L-Asparagine 70-47-3propiophenone 93-55-0 5-isopropyl-2-methyl-phenol 499-75-2 Xylitol87-99-0 ethyl 4-oxopentanoate 539-88-8 methyl cinnamate 103-26-4 cumicalcohol 536-60-7 methyl 2-naphthyl ketone 93-08-31-methyl-4-(1-methylethyl)- 99-85-4 1,4-Cyclohexadiene en-ethylenediamine Caffeine 58-08-2 5-methylfurfural 620-02-0 furfuryl acetate623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-14′-Methoxyacetophenone 100-06-1 D-Fenchone 4695-62-91-Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenone122-00-9 Methyl phenylacetate 101-41-7 4-Ethoxybenzaldehyde 10031-82-0p-tolyl acetate 140-39-6 2,6-Dimethoxyphenol 91-10-1 Methyl2-methoxybenzoate 606-45-1 alpha-methylcinnamaldehyde 101-39-32-methoxycinnamaldehyde 60125-24-8 Potassium bicarbonate 298-14-6piperonyl acetate 326-61-4 2,3-hexanedione 3848-24-6 furfural acetone623-15-4 trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9 Methylnicotinate 93-60-7 Ethyl benzoylacetate 94-02-0 Methyl 4-methoxybenzoate121-98-2 Levulinic acid 123-76-2 m-Dimethoxybenzene 151-10-02-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-42,3-dimethyl-pyrazine 5910-89-4 trimethyl-pyrazine 14667-55-12-ethyl-3-methyl-pyrazine 15707-23-0 5-Methyl-3H-furan-2-one 591-12-82-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-02-Methoxy-4-propylphenol 2785-87-7 Naphthalene, 2-(2- 2173-57-1methylpropoxy)- 2-Acetyl-1-methylpyrrole 932-16-1 3,3-Dimethylacrylicacid 541-47-9 Ethyl sorbate 2396-84-1 4-(4-Hydroxyphenyl)-2-butanone5471-51-2 4-Methoxyphenylacetone 122-84-9 (−)-Myrtenal 564-94-33-Phenylpropionaldehyde 104-53-0 1-Phenylethyl propionate 120-45-62-Methyltetrahydrofuran-3-one 3188-00-9 Cinnamyl acetate 103-54-8Styrallyl acetate 93-92-5 Ethyl 4-methoxybenzoate 94-30-4 Benzylpropionate 122-63-4 Phenylpyruvate 156-06-9 furaneol 3658-77-3 methyl2-methylbutanoate 868-57-5 Benzeneacetaldehyde, alpha- 93-53-8 methyl-Dimethyl anthranilate 85-91-6 1,1-Dimethoxy-2-phenylpropane 90-87-94-hexanolide 695-06-7 Dimethylbenzylcarbinyl acetate 151-05-3 Benzylisobutyrate 103-28-6 Acetyl isoeugenol 93-29-8 2-Acetyl-5-methyl furan1193-79-9 Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehydeBenzylcarbinyl formate 104-62-1 p-Cresyl alpha-toluate 101-94-0Potassium bisulfate 7646-93-7 Potassium carbonate 584-08-7 Potassiumchloride 7447-40-7 Potassium hydroxide 1310-58-3 Ethyl tiglate 5837-78-5Nerol oxide 1786-08-9 DL-Tetrohydrofurfuryl 637-65-0 propionateBenzaldehyde propylene glycol 2568-25-4 acetal 2-Methyl-3-(2-furyl)acrolein 874-66-8 vanillin 121-33-5 Cholic acid 81-25-4 R-Carvone6485-40-1 Potassium nitrate 7757-79-1 Potassium permanganate 7722-64-7Potassium persulfate 7727-21-1 Potassium phosphate, dibasic 2139900Potassium Phosphate Monobasic 7778-77-0 Potassium sulfate 7778-80-5Sodium bicarbonate 144-55-8 Sodium bisulfite 7631-90-5 Sodium carbonate497-19-8 Sodium chloride 7647-14-5 Sodium dithionite 7775-14-6 Sodiumhydroxide 1310-73-2 Sodium nitrite 7632-00-0 Sodium Pyrophosphate7722-88-5 Sodium sulfate 7757-82-6 Sodium sulfite 7757-83-7 Sodiumthiocyanate 540-72-7 Calcium Carbonate 471-34-1 Calcium chloride10043-52-4 Calcium gluconate 299-28-5 Calcium hydroxide 1305-62-0Calcium phosphate, dibasic 7757-93-9 Calcium sulfate 7778-18-9N-Methyl-D-glucamine 6284-40-8 Calcium oxide 1305-78-8 Calcium PhosphateMonobasic 7758-23-8 Magnesium chloride hexahydrate 7791-18-6 Magnesiumsulfate 7487-88-9 Magnesium Sulfate Heptahydrate 10034-99-8 Aluminumchloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2Aluminum potassium sulfate, 7784-24-9 dodecahydrate Aluminum sulfate,7784-31-8 octadecahydrate (S)-(−)-Cysteine 52-90-4 p-ToluenesulfonicAcid 104-15-4 Potassium bitartrate 868-14-4 DL-aspartic acid 617-45-8p-Dimethylaminobenzaldehyde 100-10-7 Sodium salicylate 54-21-7 Benzoin119-53-9 Sodium dodecyl sulfate 151-21-3 L-Menthol 2216-51-5 Tiron149-45-1 Riboflavin 83-88-5 Sodium Acetate Trihydrate 6131-90-4 DisodiumSuccinate Hexahydrate 6106-21-4 Disodium 6381-92-6ethylenediaminetetraacetate dihydrate sodium citrate, dihydrate 1545801Sodium potassium tartrate, 6381-59-5 tetrahydrate L-(+)-Arginine1119-34-2 monohydrochloride Ethylenediamine 333-18-6 dihydrochlorideSodium formate 141-53-7 Sodium acetate 127-09-3 Potassium acetate127-08-2 Ammonium citrate 3012-65-5 Ammonium bicarbonate 1066-33-7Ammonium chloride 12125-02-9 Ammonium nitrate 6484-52-2 Ammoniumpersulfate 7727-54-0 Ammonium sulfate 7783-20-2 Zinc chloride 7646-85-7Sulfuric acid, zinc salt 7446-20-0 (1:1), heptahydrate SodiumTripolyphosphate 7758-29-4 ammonium benzoate 1863-63-4 ammoniumbisulfite 10192-30-0 1,5-Naphthalenedisulfonic Acid 1655-29-4 DisodiumSalt 4-Hydroxybenzoic Acid 99-96-7 Diphenylacetic Acid 117-34-0 GlutaricAcid 110-94-1 L-(−)-Fucose 2438-80-4 L-Cysteine Hydrochloride 52-89-1L-Histidine Hydrochloride 1880304 Monohydrate o-Toluic Acid 118-90-1Pivalic Acid 75-98-9 Pyruvic Acid Sodium Salt 113-24-6 Potassium bromide2139626 Sodium Dithionate Dihydrate 7631-94-9 Sodium Malonate 141-95-7Trisodium Citrate 68-04-2 Potassium Sodium Tartrate 304-59-6 PotassiumCitrate 866-84-2 D-Maltose Monohydrate 6363-53-7 Cyclohexaamylose10016-20-3 Dodecyl sulfate, lithium salt 2044-56-6 Manganese chloride2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9 Triphosphoricacid, 13845-36-8 pentapotassium salt Glycine ethyl ester 623-33-6hydrochloride L-Histidine methyl ester 7389-87-9 dihydrochlorideL-Leucine methyl ester 7517-19-3 hydrochloride D-Lysine hydrochloride7274-88-6 2-Naphthalenesulfonic acid 532-02-5 sodium salt calciumnitrate tetrahydrate 13477-34-4 Vitamin B1 59-43-8 Zinc AcetateDihydrate 5970-45-6 Potassium fluoride 7789-23-3 Potassium iodate2139718 Potassium iodide 7681-11-0 Potassium thiocyanate 333-20-0 Sodiumbromide 7647-15-6 Sodium fluoride 7681-49-4 Sodium iodide 7681-82-5Sodium nitrate 7631-99-4 Calcium acetate 5743-26-0 Trichloroacetic acid76-03-9 Ammonium acetate 631-61-8 Ammonium fluoride 12125-01-8 DL-malicacid 617-48-1 t-Butyl Alcohol 75-65-0 beta-Alanine 107-95-9(S)-(−)-Tryptophan 73-22-3 Malonic acid 141-82-2 Phenethylamine 64-04-0Salicylylaldehyde 90-02-8 Sodium benzoate 532-32-1 Mandelic acid 90-64-2Calcium pantothenate 137-08-6 Chloroacetic Acid 79-11-8 Ethanol Amine141-43-5 Salicylic acid 69-72-7 Saccharin sodium 128-44-9 Thiaminehydrochloride 67-03-8 2,2′-Oxybisethanol 111-46-6 Resorcinol 108-46-32-Amino-2-(hydroxymethyl)-1,3- 77-86-1 propanediol 2,5-Dimethylphenol95-87-4 Ammonium Phosphate Monobasic 7722-76-1 1,3-Butanediol 107-88-0Glycolic Acid 79-14-1 Sodium Gluconate 527-07-1 Terephthalic Acid100-21-0 L-Ascorbic Acid Sodium Salt 134-03-2 3-Acetyl-6-methyl-2,4-520-45-6 pyrandione Calcium Acetate 62-54-4 Nicotinamide 98-92-01-Hydroxy-2-naphthoic Acid 86-48-6 2-Isopropylphenol 88-69-74-Aminosalicylic Acid 65-49-6 Calcium Glycerophosphate 27214-00-2Erythorbic Acid Sodium Salt 7378-23-6 Gluconic Acid Potassium Salt299-27-4 Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5 Potassium Benzoate582-25-2 Taurine 107-35-7 Thiamine Nitrate 532-43-43,3,5-Trimethyl-1-cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0Sulfosalicylic acid 97-05-2 Gallic acid 149-91-7 L-borneol 464-45-9Isoborneol 124-76-5 2,5-Dihydroxybenzoic acid, 490-79-9 Gentisic acid5-hydroxy-6-methyl-3,4- 65-23-6 pyridinedimethanolNaphthalene-2-sulfonic acid 120-18-3 Ethanesulfonic acid, 2- 1562-00-1hydroxy-, monosodium salt Pamoic acid 130-85-8 2,4-Dimethylphenol105-67-9 3,5-Dihydroxyacetophenone 51863-60-6 Eugenol 97-53-0 n-ButyricAcid 107-92-6 Hydroquinone 123-31-9 Propionic Acid 79-09-4meta-Phenylenediamine 108-45-2 Oxalic Acid 144-62-7 n-Hexanoic Acid142-62-1 2-Furancarboxylic Acid 88-14-2 4′-Nitroacetanilide 104-04-1D-(−)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1 Galactaricacid 526-99-8 D-glucuronate 1700908 Lactobionic acid 96-82-2p-Formylacetanilide 122-85-0 2-Mercaptobenzoic acid 147-93-3 Propanoicacid, 2-hydroxy-, 28305-25-1 calcium salt (2:1), (S)-D(+)-10-Camphorsulfonic acid 3144-16-9 3-Cyclopentylpropionic acid140-77-2 1R-(−)-Camphorsulfonic acid 35963-20-3 DL-Lysine 70-54-2Cinnamic acid 621-82-9 Triethanolamine 102-71-6 Acetic Acid 64-19-7Dichloroacetic Acid 79-43-6 Diethylamine 109-89-7 Diethylaminoethanol100-37-8 N-(2-Hydroxyethyl)Morpholine 622-40-2 Octanoic Acid 124-07-2isobutyric acid 79-31-2 Anisic Acid 100-09-4 Betaine 107-43-7 EnanthoicAcid 111-14-8 Hippuric Acid 495-69-2 Tiglic Acid 80-59-1Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9D-(+)-Camphoric acid 124-83-4 N-(2-Hydroxyethyl)pyrrolidine 2955-88-6Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate 7558-79-4Sodium Phosphate Monobasic 7558-80-7 Sodium thiosulfate 7772-98-71Orthoboric acid 10043-35-3 Diethanolamine 111-42-2 Benzaldehyde 100-52-7Sorbic acid 110-44-1 L-(+)-Tartaric Acid 87-69-4 D-mannitol 69-65-8Butyl paraben 94-26-8 Thymol 89-83-8 Methyl salicylate 119-36-8 Citricacid 77-92-9 Creatinine 60-27-5 Vitamin C 50-81-7 Benzoic Acid 65-85-0Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4 p-Cresol 106-44-5Aspirin 50-78-2 Phenol 108-95-2 Sucrose 57-50-1 Potassium citrate,monohydrate 1534146 Sodium acetate 127-09-3 Lactic acid 50-21-5Propionic acid, sodium salt 65-85 Benzyl alcohol 100-51-6 Phenethylalcohol 60-12-8 Cholesterol 57-88-5 D-Glucose 50-99-7 Sorbitol 50-70-4Aspartame 22839-47-0 Saccharin 81-07-2 2,6-Di-tert-Butyl-p-Cresol128-37-0 4-Chloro-3-methylphenol 59-50-7 glycerin 56-81-5 Propyl paraben94-13-3 fumaric acid 110-17-8 dabco 280-57-9 p-Phenylenediamine 106-50-3Anethole 4180-23-8 propyl gallate 121-79-9 L-monosodium glutamate142-47-2 Butylated hydroxyanisole 25013-16-5 Cyclohexanol,5-methyl-2-(1- 89-78-1 methylethyl)-, (1alpha,2beta,5alpha)-alpha-Thioglycerol 96-27-5 Sodium dehydroacetate 4418-26-2 Ethyl4-hydroxybenzoate 120-47-8 Ethyl Vanillin 121-32-4 Triacetin 102-76-1Potassium sorbate 590-00-1 Triethyl citrate 77-93-0 (S)-(+)-Arginine74-79-3 Glycine 56-40-6 (S)-(−)-Histidine 71-00-1 (S)-(+)-Lysine 56-87-1Quinone 106-51-4 Naphthalene, 2-ethoxy- 93-18-5 Methanesulfonic Acid75-75-2 DL-Tartaric Acid 133-37-9 Cyclamic acid 100-88-9(S)-(−)-Phenylalanine 63-91-2 (S)-(−)-Tyrosine 60-18-4 Carvone 99-49-0Ethyl butyrate 105-54-4 6-Methyl-5-hepten-2-one 110-93-0 Ethylacetoacetate 141-97-9 Methyl benzoate 93-58-3 Phenylacetic Acid 103-82-2Adipic acid 124-04-9 Ethyl benzoate 93-89-0 Benzyl benzoate 120-51-4Pyruvic acid 127-17-3 Succinic acid 110-15-6 Indole 120-72-9 Methylanthranilate 134-20-3 Diethyl malonate 105-53-3 Niacin 59-67-6Meso-inositol 87-89-8 4-Aminobenzoic acid 150-13-0 Anisole 100-66-3 Urea57-13-6 Pyrrolidine 123-75-1 Cyclopentanone 120-92-3 Acetic anhydride108-24-7 Benzophenone 119-61-9 D-(−)-Fructose 57-48-7 D-(+)-Xylose58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethylisovalerate 108-64-5 1,1′-Azobisformamide 123-77-3 6-Methylcoumarin92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2 Cymene 99-87-6Dimethyl Succinate 106-65-0 p-Anisaldehyde 123-11-5 Phenyl ether101-84-8 Tetrahydro-2-furanmethanol 97-99-4 Valeric Acid 109-52-43,4-xylenol 95-65-8 1,1-diethoxyethane 105-57-7 ethyl butyraldehyde97-96-1 Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 methylisovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde123-15-9 4-(2,6,6-Trimethyl-2- 127-41-3 cyclohexen-1-yl)-3-buten-2-one4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1-yl)-3-buten-2-one Maleicacid 110-16-7 3-Methylbutanoic acid 503-74-2 L-Glutamic Acid 56-86-0D-limonene 5989-27-5 1-Phenyl-1-propanol 93-54-9 2′-Hydroxyacetophenone118-93-4 2,4-Dihydroxybenzoic Acid 89-86-1 2-Phenyl-1-propanol 1123-85-93-Phenylpropionic Acid 501-52-0 4-Ethoxyphenol 622-62-8 Alpha-Terpineol98-55-5 Benzaldehyde Dimethylacetal 1125-88-8 Benzyl Ether 103-50-4Benzyl Formate 104-57-4 Benzyl Salicylate 118-58-1 Cinnamyl Alcohol104-54-1 D-(+)-Glucono-1,5-lactone 4253-68-3 D-Isoascorbic Acid 89-65-62,3-Naphthalenediol 92-44-4 Diethyl Succinate 123-25-1 Ethyl2-Aminobenzoate 87-25-2 Ethyl Cinnamate 103-36-6 Ethyl Phenylacetate101-97-3 Ethyl Salicylate 118-61-6 gamma-Valerolactone 108-29-2Hydroquinone Dimethyl Ether 150-78-7 Isocaproic Acid 646-07-1 Isoeugenol97-54-1 Isopropyl Benzoate 939-48-0 L-(+)-Isoleucine 73-32-5 L-Malicacid 97-67-6 L-2-Aminopropionic Acid 56-41-7 L-Carnitine 541-15-1L-Glutamine 56-85-9 L-Hydroxyproline 51-35-4 L-Proline 147-85-3 L-Serine56-45-1 L-Threonine 72-19-5 L-Valine 72-18-4 Phenoxyacetic Acid 122-59-8Veratrole 91-16-7 2-Ethylbutyric acid 88-09-5 2-Methylpyrazine 109-08-0o-methoxybenzaldehyde 135-02-4 L-Leucine 61-90-5 L-Asparagine 70-47-3propiophenone 93-55-0 5-isopropyl-2-methyl-phenol 499-75-2 Xylitol87-99-0 ethyl 4-oxopentanoate 539-88-8 methyl cinnamate 103-26-4 cumicalcohol 536-60-7 methyl 2-naphthyl ketone 93-08-31-methyl-4-(1-methylethyl)- 99-85-4 1,4-Cyclohexadiene en-ethylenediamine Caffeine 58-08-2 5-methylfurfural 620-02-0 furfuryl acetate623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-14′-Methoxyacetophenone 100-06-1 D-Fenchone 4695-62-91-Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenone122-00-9 Methyl phenylacetate 101-41-7 4-Ethoxybenzaldehyde 10031-82-0p-tolyl acetate 140-39-6 2,6-Dimethoxyphenol 91-10-1 Methyl2-methoxybenzoate 606-45-1 alpha-methylcinnamaldehyde 101-39-32-methoxycinnamaldehyde 60125-24-8 Potassium bicarbonate 298-14-6piperonyl acetate 326-61-4 2,3-hexanedione 3848-24-6 furfural acetone623-15-4 trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9 Methylnicotinate 93-60-7 Ethyl benzoylacetate 94-02-0 Methyl 4-methoxybenzoate121-98-2 Levulinic acid 123-76-2 m-Dimethoxybenzene 151-10-02-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-42,3-dimethyl-pyrazine 5910-89-4 trimethyl-pyrazine 14667-55-12-ethyl-3-methyl-pyrazine 15707-23-0 5-Methyl-3H-furan-2-one 591-12-82-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-02-Methoxy-4-propylphenol 2785-87-7 Naphthalene, 2-(2- 2173-57-1methylpropoxy)- 2-Acetyl-1-methylpyrrole 932-16-1 3,3-Dimethylacrylicacid 541-47-9 Ethyl sorbate 2396-84-1 4-(4-Hydroxyphenyl)-2-butanone5471-51-2 4-Methoxyphenylacetone 122-84-9 (−)-Myrtenal 564-94-33-Phenylpropionaldehyde 104-53-0 1-Phenylethyl propionate 120-45-62-Methyltetrahydrofuran-3-one 3188-00-9 Cinnamyl acetate 103-54-8Styrallyl acetate 93-92-5 Ethyl 4-methoxybenzoate 94-30-4 Benzylpropionate 122-63-4 Phenylpyruvate 156-06-9 furaneol 3658-77-3 methyl2-methylbutanoate 868-57-5 Benzeneacetaldehyde, alpha- 93-53-8 methyl-Dimethyl anthranilate 85-91-6 1,1-Dimethoxy-2-phenylpropane 90-87-94-hexanolide 695-06-7 Dimethylbenzylcarbinyl acetate 151-05-3 Benzylisobutyrate 103-28-6 Acetyl isoeugenol 93-29-8 2-Acetyl-5-methyl furan1193-79-9 Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehydeBenzylcarbinyl formate 104-62-1 p-Cresyl alpha-toluate 101-94-0Potassium bisulfate 7646-93-7 Potassium carbonate 584-08-7 Potassiumchloride 7447-40-7 Potassium hydroxide 1310-58-3 Ethyl tiglate 5837-78-5Nerol oxide 1786-08-9 DL-Tetrohydrofurfuryl 637-65-0 propionateBenzaldehyde propylene glycol 2568-25-4 acetal 2-Methyl-3-(2-furyl)acrolein 874-66-8 vanillin 121-33-5 Cholic acid 81-25-4 R-Carvone6485-40-1 Potassium nitrate 7757-79-1 Potassium permanganate 7722-64-7Potassium persulfate 7727-21-1 Potassium phosphate, dibasic 2139900Potassium Phosphate Monobasic 7778-77-0 Potassium sulfate 7778-80-5Sodium bicarbonate 144-55-8 Sodium bisulfite 7631-90-5 Sodium carbonate497-19-8 Sodium chloride 7647-14-5 Sodium dithionite 7775-14-6 Sodiumhydroxide 1310-73-2 Sodium nitrite 7632-00-0 Sodium Pyrophosphate7722-88-5 Sodium sulfate 7757-82-6 Sodium sulfite 7757-83-7 Sodiumthiocyanate 540-72-7 Calcium Carbonate 471-34-1 Calcium chloride10043-52-4 Calcium gluconate 299-28-5 Calcium hydroxide 1305-62-0Calcium phosphate, dibasic 7757-93-9 Calcium sulfate 7778-18-9N-Methyl-D-glucamine 6284-40-8 Calcium oxide 1305-78-8 Calcium PhosphateMonobasic 7758-23-8 Magnesium chloride hexahydrate 7791-18-6 Magnesiumsulfate 7487-88-9 Magnesium Sulfate Heptahydrate 10034-99-8 Aluminumchloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2Aluminum potassium sulfate, 7784-24-9 dodecahydrate Aluminum sulfate,7784-31-8 octadecahydrate (S)-(−)-Cysteine 52-90-4 p-ToluenesulfonicAcid 104-15-4 Potassium bitartrate 868-14-4 DL-aspartic acid 617-45-8p-Dimethylaminobenzaldehyde 100-10-7 Sodium salicylate 54-21-7 Benzoin119-53-9 Sodium dodecyl sulfate 151-21-3 L-Menthol 2216-51-5 Tiron149-45-1 Riboflavin 83-88-5 Sodium Acetate Trihydrate 6131-90-4 DisodiumSuccinate Hexahydrate 6106-21-4 Disodium 6381-92-6ethylenediaminetetraacetate dihydrate sodium citrate, dihydrate 1545801Sodium potassium tartrate, 6381-59-5 tetrahydrate L-(+)-Arginine1119-34-2 monohydrochloride Ethylenediamine 333-18-6 dihydrochlorideSodium formate 141-53-7 Sodium acetate 127-09-3 Potassium acetate127-08-2 Ammonium citrate 3012-65-5 Ammonium bicarbonate 1066-33-7Ammonium chloride 12125-02-9 Ammonium nitrate 6484-52-2 Ammoniumpersulfate 7727-54-0 Ammonium sulfate 7783-20-2 Zinc chloride 7646-85-7Sulfuric acid, zinc salt 7446-20-0 (1:1), heptahydrate SodiumTripolyphosphate 7758-29-4 ammonium benzoate 1863-63-4 ammoniumbisulfite 10192-30-0 1,5-Naphthalenedisulfonic Acid 1655-29-4 DisodiumSalt 4-Hydroxybenzoic Acid 99-96-7 Diphenylacetic Acid 117-34-0 GlutaricAcid 110-94-1 L-(−)-Fucose 2438-80-4 L-Cysteine Hydrochloride 52-89-1L-Histidine Hydrochloride 1880304 Monohydrate o-Toluic Acid 118-90-1Pivalic Acid 75-98-9 Pyruvic Acid Sodium Salt 113-24-6 Potassium bromide2139626 Sodium Dithionate Dihydrate 7631-94-9 Sodium Malonate 141-95-7Trisodium Citrate 68-04-2 Potassium Sodium Tartrate 304-59-6 PotassiumCitrate 866-84-2 D-Maltose Monohydrate 6363-53-7 Cyclohexaamylose10016-20-3 Dodecyl sulfate, lithium salt 2044-56-6 Manganese chloride2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9 Triphosphoricacid, 13845-36-8 pentapotassium salt Glycine ethyl ester 623-33-6hydrochloride L-Histidine methyl ester 7389-87-9 dihydrochlorideL-Leucine methyl ester 7517-19-3 hydrochloride D-Lysine hydrochloride7274-88-6 2-Naphthalenesulfonic acid 532-02-5 sodium salt calciumnitrate tetrahydrate 13477-34-4 Vitamin B1 59-43-8 Zinc AcetateDihydrate 5970-45-6 Potassium fluoride 7789-23-3 Potassium iodate2139718 Potassium iodide 7681-11-0 Potassium thiocyanate 333-20-0 Sodiumbromide 7647-15-6 Sodium fluoride 7681-49-4 Sodium iodide 7681-82-5Sodium nitrate 7631-99-4 Calcium acetate 5743-26-0 Trichloroacetic acid76-03-9 Ammonium acetate 631-61-8 Ammonium fluoride 12125-01-8 DL-malicacid 617-48-1 t-Butyl Alcohol 75-65-0 beta-Alanine 107-95-9(S)-(−)-Tryptophan 73-22-3 Malonic acid 141-82-2 Phenethylamine 64-04-0Salicylylaldehyde 90-02-8 Sodium benzoate 532-32-1 Mandelic acid 90-64-2Calcium pantothenate 137-08-6 Chloroacetic Acid 79-11-8 Ethanol Amine141-43-5 Salicylic acid 69-72-7 Saccharin sodium 128-44-9 Thiaminehydrochloride 67-03-8 2,2′-Oxybisethanol 111-46-6 Resorcinol 108-46-32-Amino-2-(hydroxymethyl)-1,3- 77-86-1 propanediol 2,5-Dimethylphenol95-87-4 Ammonium Phosphate Monobasic 7722-76-1 1,3-Butanediol 107-88-0Glycolic Acid 79-14-1 Sodium Gluconate 527-07-1 Terephthalic Acid100-21-0 L-Ascorbic Acid Sodium Salt 134-03-2 3-Acetyl-6-methyl-2,4-520-45-6 pyrandione Calcium Acetate 62-54-4 Nicotinamide 98-92-01-Hydroxy-2-naphthoic Acid 86-48-6 2-Isopropylphenol 88-69-74-Aminosalicylic Acid 65-49-6 Calcium Glycerophosphate 27214-00-2Erythorbic Acid Sodium Salt 7378-23-6 Gluconic Acid Potassium Salt299-27-4 Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5 Potassium Benzoate582-25-2 Taurine 107-35-7 Thiamine Nitrate 532-43-43,3,5-Trimethyl-1-cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0Sulfosalicylic acid 97-05-2 Gallic acid 149-91-7 L-borneol 464-45-9Isoborneol 124-76-5 2,5-Dihydroxybenzoic acid, 490-79-9 Gentisic acid5-hydroxy-6-methyl-3,4- 65-23-6 pyridinedimethanolNaphthalene-2-sulfonic acid 120-18-3 Ethanesulfonic acid, 2- 1562-00-1hydroxy-, monosodium salt Pamoic acid 130-85-8 2,4-Dimethylphenol105-67-9 3,5-Dihydroxyacetophenone 51863-60-6 Eugenol 97-53-0 n-ButyricAcid 107-92-6 Hydroquinone 123-31-9 Propionic Acid 79-09-4meta-Phenylenediamine 108-45-2 Oxalic Acid 144-62-7 n-Hexanoic Acid142-62-1 2-Furancarboxylic Acid 88-14-2 4′-Nitroacetanilide 104-04-1D-(−)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1 Galactaricacid 526-99-8 D-glucuronate 1700908 Lactobionic acid 96-82-2p-Formylacetanilide 122-85-0 2-Mercaptobenzoic acid 147-93-3 Propanoicacid, 2-hydroxy-, 28305-25-1 calcium salt (2:1), (S)-D(+)-10-Camphorsulfonic acid 3144-16-9 3-Cyclopentylpropionic acid140-77-2 1R-(−)-Camphorsulfonic acid 35963-20-3 DL-Lysine 70-54-2Cinnamic acid 621-82-9 Triethanolamine 102-71-6 Acetic Acid 64-19-7Dichloroacetic Acid 79-43-6 Diethylamine 109-89-7 Diethylaminoethanol100-37-8 N-(2-Hydroxyethyl)Morpholine 622-40-2 Octanoic Acid 124-07-2isobutyric acid 79-31-2 Anisic Acid 100-09-4 Betaine 107-43-7 EnanthoicAcid 111-14-8 Hippuric Acid 495-69-2 Tiglic Acid 80-59-1Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9D-(+)-Camphoric acid 124-83-4 N-(2-Hydroxyethyl)pyrrolidine 2955-88-6Sodium Metabisulfite 7681-57-4 sodium hydrogen phosphate 7558-79-4Sodium Phosphate Monobasic 7558-80-7 Sodium thiosulfate 7772-98-71Orthoboric acid 10043-35-3 Diethanolamine 111-42-2 Benzaldehyde 100-52-7Sorbic acid 110-44-1 L-(+)-Tartaric Acid 87-69-4 D-mannitol 69-65-8Butyl paraben 94-26-8 Thymol 89-83-8 Methyl salicylate 119-36-8 Citricacid 77-92-9 Creatinine 60-27-5 Vitamin C 50-81-7 Benzoic Acid 65-85-0Methyl 4-hydroxybenzoate 99-76-3 m-Cresol 108-39-4 p-Cresol 106-44-5Aspirin 50-78-2 Phenol 108-95-2 Sucrose 57-50-1 Potassium citrate,monohydrate 1534146 Sodium acetate 127-09-3 Lactic acid 50-21-5Propionic acid, sodium salt 65-85 Benzyl alcohol 100-51-6 Phenethylalcohol 60-12-8 Cholesterol 57-88-5 D-Glucose 50-99-7 Sorbitol 50-70-4Aspartame 22839-47-0 Saccharin 81-07-2 2,6-Di-tert-Butyl-p-Cresol128-37-0 4-Chloro-3-methylphenol 59-50-7 glycerin 56-81-5 Propyl paraben94-13-3 fumaric acid 110-17-8 dabco 280-57-9 p-Phenylenediamine 106-50-3Anethole 4180-23-8 propyl gallate 121-79-9 L-monosodium glutamate142-47-2 Butylated hydroxyanisole 25013-16-5 Cyclohexanol,5-methyl-2-(1- 89-78-1 methylethyl)-, (1alpha,2beta,5alpha)-alpha-Thioglycerol 96-27-5 Sodium dehydroacetate 4418-26-2 Ethyl4-hydroxybenzoate 120-47-8 Ethyl Vanillin 121-32-4 Triacetin 102-76-1Potassium sorbate 590-00-1 Triethyl citrate 77-93-0 (S)-(+)-Arginine74-79-3 Glycine 56-40-6 (S)-(−)-Histidine 71-00-1 (S)-(+)-Lysine 56-87-1Quinone 106-51-4 Naphthalene, 2-ethoxy- 93-18-5 Methanesulfonic Acid75-75-2 DL-Tartaric Acid 133-37-9 Cyclamic acid 100-88-9(S)-(−)-Phenylalanine 63-91-2 (S)-(−)-Tyrosine 60-18-4 Carvone 99-49-0Ethyl butyrate 105-54-4 6-Methyl-5-hepten-2-one 110-93-0 Ethylacetoacetate 141-97-9 Methyl benzoate 93-58-3 Phenylacetic Acid 103-82-2Adipic acid 124-04-9 Ethyl benzoate 93-89-0 Benzyl benzoate 120-51-4Pyruvic acid 127-17-3 Succinic acid 110-15-6 Indole 120-72-9 Methylanthranilate 134-20-3 Diethyl malonate 105-53-3 Niacin 59-67-6Meso-inositol 87-89-8 4-Aminobenzoic acid 150-13-0 Anisole 100-66-3 Urea57-13-6 Pyrrolidine 123-75-1 Cyclopentanone 120-92-3 Acetic anhydride108-24-7 Benzophenone 119-61-9 D-(−)-Fructose 57-48-7 D-(+)-Xylose58-86-6 o-Methoxybenzoic Acid 579-75-9 linalool 78-70-6 ethylisovalerate 108-64-5 1,1′-Azobisformamide 123-77-3 6-Methylcoumarin92-48-8 acetoin 513-86-0 alpha-Phellandrene 99-83-2 Cymene 99-87-6Dimethyl Succinate 106-65-0 p-Anisaldehyde 123-11-5 Phenyl ether101-84-8 Tetrahydro-2-furanmethanol 97-99-4 Valeric Acid 109-52-43,4-xylenol 95-65-8 1,1-diethoxyethane 105-57-7 ethyl butyraldehyde97-96-1 Ethyl crotonate 623-70-1 ethyl isobutyrate 97-62-1 methylisovalerate 556-24-1 methyl propionate 554-12-1 methyl valeraldehyde123-15-9 4-(2,6,6-Trimethyl-2- 127-41-3 cyclohexen-1-yl)-3-buten-2-one4-(2,6,6-trimethyl-1- 14901-07-6 cyclohexen-1-yl)-3-buten-2-one Maleicacid 110-16-7 3-Methylbutanoic acid 503-74-2 L-Glutamic Acid 56-86-0D-limonene 5989-27-5 1-Phenyl-1-propanol 93-54-9 2′-Hydroxyacetophenone118-93-4 2,4-Dihydroxybenzoic Acid 89-86-1 2-Phenyl-1-propanol 1123-85-93-Phenylpropionic Acid 501-52-0 4-Ethoxyphenol 622-62-8 Alpha-Terpineol98-55-5 Benzaldehyde Dimethylacetal 1125-88-8 Benzyl Ether 103-50-4Benzyl Formate 104-57-4 Benzyl Salicylate 118-58-1 Cinnamyl Alcohol104-54-1 D-(+)-Glucono-1,5-lactone 4253-68-3 D-Isoascorbic Acid 89-65-62,3-Naphthalenediol 92-44-4 Diethyl Succinate 123-25-1 Ethyl2-Aminobenzoate 87-25-2 Ethyl Cinnamate 103-36-6 Ethyl Phenylacetate101-97-3 Ethyl Salicylate 118-61-6 gamma-Valerolactone 108-29-2Hydroquinone Dimethyl Ether 150-78-7 Isocaproic Acid 646-07-1 Isoeugenol97-54-1 Isopropyl Benzoate 939-48-0 L-(+)-Isoleucine 73-32-5 L-Malicacid 97-67-6 L-2-Aminopropionic Acid 56-41-7 L-Carnitine 541-15-1L-Glutamine 56-85-9 L-Hydroxyproline 51-35-4 L-Proline 147-85-3 L-Serine56-45-1 L-Threonine 72-19-5 L-Valine 72-18-4 Phenoxyacetic Acid 122-59-8Veratrole 91-16-7 2-Ethylbutyric acid 88-09-5 2-Methylpyrazine 109-08-0o-methoxybenzaldehyde 135-02-4 L-Leucine 61-90-5 L-Asparagine 70-47-3propiophenone 93-55-0 5-isopropyl-2-methyl-phenol 499-75-2 Xylitol87-99-0 ethyl 4-oxopentanoate 539-88-8 methyl cinnamate 103-26-4 cumicalcohol 536-60-7 methyl 2-naphthyl ketone 93-08-31-methyl-4-(1-methylethyl)- 99-85-4 1,4-Cyclohexadiene en-ethylenediamine Caffeine 58-08-2 5-methylfurfural 620-02-0 furfuryl acetate623-17-6 terpinen-4-ol 10482-56-1 phenylethanal 122-78-14′-Methoxyacetophenone 100-06-1 D-Fenchone 4695-62-91-Methoxy-4-methylbenzene 104-93-8 o-methylanisole 578-58-5Acetylacetaldehyde dimethyl 5436-21-5 acetal p-methylacetophenone122-00-9 Methyl phenylacetate 101-41-7 4-Ethoxybenzaldehyde 10031-82-0p-tolyl acetate 140-39-6 2,6-Dimethoxyphenol 91-10-1 Methyl2-methoxybenzoate 606-45-1 alpha-methylcinnamaldehyde 101-39-32-methoxycinnamaldehyde 60125-24-8 Potassium bicarbonate 298-14-6piperonyl acetate 326-61-4 2,3-hexanedione 3848-24-6 furfural acetone623-15-4 trans beta-(2-furyl)acrolein 623-30-3 carveol 99-48-9 Methylnicotinate 93-60-7 Ethyl benzoylacetate 94-02-0 Methyl 4-methoxybenzoate121-98-2 Levulinic acid 123-76-2 m-Dimethoxybenzene 151-10-02-acetylpyridine 1122-62-9 tetramethyl-pyrazine 1124-11-42,3-dimethyl-pyrazine 5910-89-4 trimethyl-pyrazine 14667-55-12-ethyl-3-methyl-pyrazine 15707-23-0 5-Methyl-3H-furan-2-one 591-12-82-Methoxy-4-methylphenol 93-51-6 piperazine 110-85-02-Methoxy-4-propylphenol 2785-87-7 Naphthalene, 2-(2- 2173-57-1methylpropoxy)- 2-Acetyl-1-methylpyrrole 932-16-1 3,3-Dimethylacrylicacid 541-47-9 Ethyl sorbate 2396-84-1 4-(4-Hydroxyphenyl)-2-butanone5471-51-2 4-Methoxyphenylacetone 122-84-9 (−)-Myrtenal 564-94-33-Phenylpropionaldehyde 104-53-0 1-Phenylethyl propionate 120-45-62-Methyltetrahydrofuran-3-one 3188-00-9 Cinnamyl acetate 103-54-8Styrallyl acetate 93-92-5 Ethyl 4-methoxybenzoate 94-30-4 Benzylpropionate 122-63-4 Phenylpyruvate 156-06-9 furaneol 3658-77-3 methyl2-methylbutanoate 868-57-5 Benzeneacetaldehyde, alpha- 93-53-8 methyl-Dimethyl anthranilate 85-91-6 1,1-Dimethoxy-2-phenylpropane 90-87-94-hexanolide 695-06-7 Dimethylbenzylcarbinyl acetate 151-05-3 Benzylisobutyrate 103-28-6 Acetyl isoeugenol 93-29-8 2-Acetyl-5-methyl furan1193-79-9 Alpha-methyl-p- 103-95-7 isopropylphenylpropanaldehydeBenzylcarbinyl formate 104-62-1 p-Cresyl alpha-toluate 101-94-0Potassium bisulfate 7646-93-7 Potassium carbonate 584-08-7 Potassiumchloride 7447-40-7 Potassium hydroxide 1310-58-3 Ethyl tiglate 5837-78-5Nerol oxide 1786-08-9 DL-Tetrohydrofurfuryl 637-65-0 propionateBenzaldehyde propylene glycol 2568-25-4 acetal 2-Methyl-3-(2-furyl)acrolein 874-66-8 vanillin 121-33-5 Cholic acid 81-25-4 R-Carvone6485-40-1 Potassium nitrate 7757-79-1 Potassium permanganate 7722-64-7Potassium persulfate 7727-21-1 Potassium phosphate, dibasic 2139900Potassium Phosphate Monobasic 7778-77-0 Potassium sulfate 7778-80-5Sodium bicarbonate 144-55-8 Sodium bisulfite 7631-90-5 Sodium carbonate497-19-8 Sodium chloride 7647-14-5 Sodium dithionite 7775-14-6 Sodiumhydroxide 1310-73-2 Sodium nitrite 7632-00-0 Sodium Pyrophosphate7722-88-5 Sodium sulfate 7757-82-6 Sodium sulfite 7757-83-7 Sodiumthiocyanate 540-72-7 Calcium Carbonate 471-34-1 Calcium chloride10043-52-4 Calcium gluconate 299-28-5 Calcium hydroxide 1305-62-0Calcium phosphate, dibasic 7757-93-9 Calcium sulfate 7778-18-9N-Methyl-D-glucamine 6284-40-8 Calcium oxide 1305-78-8 Calcium PhosphateMonobasic 7758-23-8 Magnesium chloride hexahydrate 7791-18-6 Magnesiumsulfate 7487-88-9 Magnesium Sulfate Heptahydrate 10034-99-8 Aluminumchloride hexahydrate 7784-13-6 aluminum nitrate nonahydrate 7784-27-2Aluminum potassium sulfate, 7784-24-9 dodecahydrate Aluminum sulfate,7784-31-8 octadecahydrate (S)-(−)-Cysteine 52-90-4 p-ToluenesulfonicAcid 104-15-4 Potassium bitartrate 868-14-4 DL-aspartic acid 617-45-8p-Dimethylaminobenzaldehyde 100-10-7 Sodium salicylate 54-21-7 Benzoin119-53-9 Sodium dodecyl sulfate 151-21-3 L-Menthol 2216-51-5 Tiron149-45-1 Riboflavin 83-88-5 Sodium Acetate Trihydrate 6131-90-4 DisodiumSuccinate Hexahydrate 6106-21-4 Disodium 6381-92-6ethylenediaminetetraacetate dihydrate sodium citrate, dihydrate 1545801Sodium potassium tartrate, 6381-59-5 tetrahydrate L-(+)-Arginine1119-34-2 monohydrochloride Ethylenediamine 333-18-6 dihydrochlorideSodium formate 141-53-7 Sodium acetate 127-09-3 Potassium acetate127-08-2 Ammonium citrate 3012-65-5 Ammonium bicarbonate 1066-33-7Ammonium chloride 12125-02-9 Ammonium nitrate 6484-52-2 Ammoniumpersulfate 7727-54-0 Ammonium sulfate 7783-20-2 Zinc chloride 7646-85-7Sulfuric acid, zinc salt 7446-20-0 (1:1), heptahydrate SodiumTripolyphosphate 7758-29-4 ammonium benzoate 1863-63-4 ammoniumbisulfite 10192-30-0 1,5-Naphthalenedisulfonic Acid 1655-29-4 DisodiumSalt 4-Hydroxybenzoic Acid 99-96-7 Diphenylacetic Acid 117-34-0 GlutaricAcid 110-94-1 L-(−)-Fucose 2438-80-4 L-Cysteine Hydrochloride 52-89-1L-Histidine Hydrochloride 1880304 Monohydrate o-Toluic Acid 118-90-1Pivalic Acid 75-98-9 Pyruvic Acid Sodium Salt 113-24-6 Potassium bromide2139626 Sodium Dithionate Dihydrate 7631-94-9 Sodium Malonate 141-95-7Trisodium Citrate 68-04-2 Potassium Sodium Tartrate 304-59-6 PotassiumCitrate 866-84-2 D-Maltose Monohydrate 6363-53-7 Cyclohexaamylose10016-20-3 Dodecyl sulfate, lithium salt 2044-56-6 Manganese chloride2145076 methyl-urea 598-50-5 beta-Cyclodextrin 7585-39-9 Triphosphoricacid, 13845-36-8 pentapotassium salt Glycine ethyl ester 623-33-6hydrochloride L-Histidine methyl ester 7389-87-9 dihydrochlorideL-Leucine methyl ester 7517-19-3 hydrochloride D-Lysine hydrochloride7274-88-6 2-Naphthalenesulfonic acid 532-02-5 sodium salt calciumnitrate tetrahydrate 13477-34-4 Vitamin B1 59-43-8 Zinc AcetateDihydrate 5970-45-6 Potassium fluoride 7789-23-3 Potassium iodate2139718 Potassium iodide 7681-11-0 Potassium thiocyanate 333-20-0 Sodiumbromide 7647-15-6 Sodium fluoride 7681-49-4 Sodium iodide 7681-82-5Sodium nitrate 7631-99-4 Calcium acetate 5743-26-0 Trichloroacetic acid76-03-9 Ammonium acetate 631-61-8 Ammonium fluoride 12125-01-8 DL-malicacid 617-48-1 t-Butyl Alcohol 75-65-0 beta-Alanine 107-95-9(S)-(−)-Tryptophan 73-22-3 Malonic acid 141-82-2 Phenethylamine 64-04-0Salicylylaldehyde 90-02-8 Sodium benzoate 532-32-1 Mandelic acid 90-64-2Calcium pantothenate 137-08-6 Chloroacetic Acid 79-11-8 Ethanol Amine141-43-5 Salicylic acid 69-72-7 Saccharin sodium 128-44-9 Thiaminehydrochloride 67-03-8 2,2′-Oxybisethanol 111-46-6 Resorcinol 108-46-32-Amino-2-(hydroxymethyl)-1,3- 77-86-1 propanediol 2,5-Dimethylphenol95-87-4 Ammonium Phosphate Monobasic 7722-76-1 1,3-Butanediol 107-88-0Glycolic Acid 79-14-1 Sodium Gluconate 527-07-1 Terephthalic Acid100-21-0 L-Ascorbic Acid Sodium Salt 134-03-2 3-Acetyl-6-methyl-2,4-520-45-6 pyrandione Calcium Acetate 62-54-4 Nicotinamide 98-92-01-Hydroxy-2-naphthoic Acid 86-48-6 2-Isopropylphenol 88-69-74-Aminosalicylic Acid 65-49-6 Calcium Glycerophosphate 27214-00-2Erythorbic Acid Sodium Salt 7378-23-6 Gluconic Acid Potassium Salt299-27-4 Orotic Acid 65-86-1 p-Anise Alcohol 105-13-5 Potassium Benzoate582-25-2 Taurine 107-35-7 Thiamine Nitrate 532-43-43,3,5-Trimethyl-1-cyclohexanol 116-02-9 tert-Butylhydroquinone 1948-33-0Sulfosalicylic acid 97-05-2 Gallic acid 149-91-7 L-borneol 464-45-9Isoborneol 124-76-5 2,5-Dihydroxybenzoic acid, 490-79-9 Gentisic acid5-hydroxy-6-methyl-3,4- 65-23-6 pyridinedimethanolNaphthalene-2-sulfonic acid 120-18-3 Ethanesulfonic acid, 2- 1562-00-1hydroxy-, monosodium salt Pamoic acid 130-85-8 2,4-Dimethylphenol105-67-9 3,5-Dihydroxyacetophenone 51863-60-6 Eugenol 97-53-0 n-ButyricAcid 107-92-6 Hydroquinone 123-31-9 Propionic Acid 79-09-4meta-Phenylenediamine 108-45-2 Oxalic Acid 144-62-7 n-Hexanoic Acid142-62-1 2-Furancarboxylic Acid 88-14-2 4′-Nitroacetanilide 104-04-1D-(−)-Tartaric Acid 147-71-7 p-Acetamidobenzoic Acid 556-08-1 Galactaricacid 526-99-8 D-glucuronate 1700908 Lactobionic acid 96-82-2p-Formylacetanilide 122-85-0 2-Mercaptobenzoic acid 147-93-3 Propanoicacid, 2-hydroxy-, 28305-25-1 calcium salt (2:1), (S)-D(+)-10-Camphorsulfonic acid 3144-16-9 3-Cyclopentylpropionic acid140-77-2 1R-(−)-Camphorsulfonic acid 35963-20-3 DL-Lysine 70-54-2Cinnamic acid 621-82-9 Triethanolamine 102-71-6 Acetic Acid 64-19-7Dichloroacetic Acid 79-43-6 Diethylamine 109-89-7 Diethylaminoethanol100-37-8 N-(2-Hydroxyethyl)Morpholine 622-40-2 Octanoic Acid 124-07-2isobutyric acid 79-31-2 Anisic Acid 100-09-4 Betaine 107-43-7 EnanthoicAcid 111-14-8 Hippuric Acid 495-69-2 Tiglic Acid 80-59-1Cyclohexanecarboxylic acid 98-89-5 m-Methoxybenzoic acid 586-38-9D-(+)-Camphoric acid 124-83-4 N-(2-Hydroxyethyl)pyrrolidine 2955-88-6

TABLE 4 Crystal data and structure refinement for Fluoxetine HCl:Benzoicacid (1:1). Identification code Fluoxetine HCl:Benzoic acid (1:1)Empirical formula C24H25ClF3NO3 Formula weight 467.90 Temperature 100(2)K Wavelength 0.71073 Å Crystal system Monoclinic Space group P2(1)/nUnit cell dimensions a = 14.806(5) Å α = 90°. b = 13.179(4) Å β =97.738(13)°. c = 24.417(7) Å γ = 90°. Volume 4721(2) Å³ Z 8 Density(calculated) 1.317 Mg/m³ Absorption coefficient 0.210 mm⁻¹ F(000) 1952Crystal size 0.47 × 0.15 × 0.10 mm³ Theta range for data collection 1.52to 33.07°. Index ranges −22 <= h <= 22, −20 <= k <= 20, −37 <= l <= 37Reflections collected 82494 Independent reflections 17030 [R(int) =0.0751] Completeness to theta = 33.07° 95.0% Absorption correction NoneRefinement method Full-matrix least-squares on F²Data/restraints/parameters 17030/0/581 Goodness-of-fit on F² 1.053 FinalR indices [I > 2sigma(I)] R1 = 0.0853, wR2 = 0.1933 R indices (all data)R1 = 0.1330, wR2 = 0.2168 Largest diff. peak and hole 2.571 and −0.689 e· Å⁻³

TABLE 5 Crystal data and structure refinement for FluoxetineHCl-succinic acid (2:1). Identification code Fluoxetine HCl-succinicacid (2:1) Empirical formula C38H42Cl2F6N2O6 Formula weight 807.64Temperature 100(2) K Wavelength 0.71073 Å Crystal system OrthorhombicSpace group Pbcn Unit cell dimensions a = 26.620(2) Å α = 90°. b =7.2147(7) Å β = 90°. c = 20.8315(19) Å γ = 90°. Volume 4000.8(6) Å³ Z 4Density (calculated) 1.341 Mg/m³ Absorption coefficient 0.236 mm⁻¹F(000) 1680 Crystal size 0.21 × 0.18 × 0.09 mm³ Theta range for datacollection 1.53 to 27.50°. Index ranges −34 <= h <= 34, −9 <= k <= 9,−26 <= l <= 27 Reflections collected 37123 Independent reflections 4600[R(int) = 0.0748] Completeness to theta = 27.50° 100.0% Absorptioncorrection Semi-empirical from equivalents Max. and min. transmission1.000 and 0.813837 Refinement method Full-matrix least-squares on F²Data/restraints/parameters 4600/0/249 Goodness-of-fit on F² 1.156 FinalR indices [I > 2sigma(I)] R1 = 0.0786, wR2 = 0.1782 R indices (all data)R1 = 0.0911, wR2 = 0.1852 Largest diff. peak and hole 0.682 and −0.499 e· Å⁻³

TABLE 6 Crystal data and structure refinement forNabumetone:2,3-naphthalenediol (1:1). Identification codeNabumetone:2,3-naphthalenediol (1:1) Empirical formula C25H24O4 Formulaweight 388.44 Temperature 100(2) K Wavelength 1.54178 Å Crystal systemMonoclinic Space group P2(1)/n Unit cell dimensions a = 17.1585(7) Å α =90°. b = 5.5168(3) Å β = 91.319(3)°. c = 20.7083(9) Å γ = 90°. Volume1959.73(16) Å³ Z 4 Density (calculated) 1.317 Mg/m³ Absorptioncoefficient 0.710 mm⁻¹ F(000) 824 Crystal size 0.21 × 0.08 × 0.025 mm³Theta range for data collection 3.31 to 66.15°. Index ranges −17 <= h <=19, −6 <= k <= 5, −24 <= l <= 23 Reflections collected 8803 Independentreflections 3063 [R(int) = 0.0801] Completeness to theta = 66.15° 89.1%Absorption correction None Refinement method Full-matrix least-squareson F² Data/restraints/parameters 3063/2/266 Goodness-of-fit on F² 1.019Final R indices [I > 2sigma(I)] R1 = 0.0528, wR2 = 0.1332 R indices (alldata) R1 = 0.1116, wR2 = 0.1692 Largest diff. peak and hole 0.277 and−0.325 e · Å⁻³

TABLE 7 Crystal data and structure refinement for Fluoxetine HCl-fumaricacid (2:1). Identification code a6g41m Empirical formula C38H42Cl2F6N2O6Formula weight 807.64 Temperature 173(2) K Wavelength 1.54178 Å Crystalsystem Orthorhombic Space group Pbcn Unit cell dimensions a = 26.6914(8)Å α = 90°. b = 7.1807(3) Å β = 90°. c = 20.6546(7) Å γ = 90°. Volume3958.7(2) Å³ Z 4 Density (calculated) 1.355 Mg/m³ Absorption coefficient2.130 mm⁻¹ F(000) 1680 Crystal size 0.20 × 0.14 × 0.08 mm³ Theta rangefor data collection 3.31 to 58.93°. Index ranges −24 <= h <= 29, −7 <= k<= 7, −21 <= l <= 22 Reflections collected 15698 Independent reflections2823 [R(int) = 0.1693] Completeness to theta = 58.93° 99.7% Absorptioncorrection None Refinement method Full-matrix least-squares on F²Data/restraints/parameters 2823/0/246 Goodness-of-fit on F² 1.018 FinalR indices [I > 2sigma(I)] R1 = 0.0469, wR2 = 0.0927 R indices (all data)R1 = 0.0940, wR2 = 0.1197 Largest diff. peak and hole 0.583 and −0.750 e· Å⁻³

1. A method of modifying one or more physical properties of an API saltcomprising the steps of: dissolving an API salt and a guest capable ofcoordinating with an anion of the API salt via hydrogen bonding in anorganic solvent to make a solution of the API salt and the guest, andsubjecting the solution to crystallization conditions to form acocrystal of the API salt and the guest.
 2. The method of claim 1further comprising the steps of measuring the solubility of thecocrystal of the API salt and the guest and measuring the solubility ofthe API salt.
 3. The method of claim 1 wherein the API salt is an HCIsalt.
 4. The method of claim 1 wherein the guest is a carboxylic acidcontaining 4 or more carbon atoms.
 5. The method of claim 4 wherein thecarboxylic acid having at least 4 carbons is selected from benzoic acid,succinic acid, and fumaric acid.
 6. The method of claim 1 wherein theguest is a carboxylic acid containing 4 or more carbon atoms.
 7. Themethod of claim 4 wherein the carboxylic acid having at least 4 carbonsis selected from benzoic acid, succinic acid, and fumaric acid.
 8. Themethod of claim 1 further comprising, prior to the dissolving step, thestep of preparing a physical mixture of the hydrochloric acid salt ofthe active agent and the carboxylic acid.